Cimetidine, an H2 receptor antagonist, is widely used in the treatment of duodenal ulcer, ZollingerEllison Syndrome (Binder et al., 1978; Winship, 1978; Ippoliti et al., 1978; Gray et al., 1978; Lc Canthy, 1978) benign gastric ulcer, gastric erosions and oesophagitis (Freston, 1979; Frost et al., 1977; Englert et al., 1978). In human beings it has a circulating half life of disappearance of 123...

Introduction: One of the most prevalent gastrointestinal ailments is gastric ulcer, which caused by an imbalance between protective and aggressive factors. Zea mays Corn a significant cereal crop containing natural phytochemical substances that are sources nourishment. The methanolic extract Corn, according to previous study, lowers stomach acidity inhibits percentage ulceration with no knowled...

The rate of endoscopically confirmed gastric ulcer relapse was compared in two groups of patients with newly healed benign gastric ulcers, receiving either cimetidine 400 mg nocte or matching placebo, over a period of 1 year. Six of 24 (25%) patients on cimetidine and 16 of 27 (59%) patients on placebo had endoscopically confirmed relapse. These included two patients in each group with asymptom...

Agnitundirasa was tested for antigastric ulcer activity in shay rat model. Oral dose of 10 mg/kg reduced the ulceration in shay rat. With 20mg/kg dose the ulceration was completely absent. The antigastric ulcer activity of agnitundirasa (20 mg/kg) was found to be equal to the effect produced by cimetidine (20 mg/kg). The reduction in gastric acidity was more with cimetidine and the reduction in...

Large doses of the imidazoline alpha 2 adrenoreceptor agonist clonidine aggravate ethanol-induced gastric lesions. The alpha 2 adrenoceptor antagonist phentolamine, the opioid antagonist naloxone and the H2 antagonist cimetidine do not prevent this action of clonidine suggesting that it is not mediated by alpha 2, opioid or H2 receptors. Further, like clonidine, high doses of phentolamine and c...

Peptic ulcer is a common problem in advanced renal failure, but most drugs for ulcers are hazardous in this condition. In a small open study cimetidine was given to nine patients with acid hypersecretion and endoscopically diagnosed duodenal ulceration who were undergoing haemodialysis. The patients obtained good pain relief and suffered no serious side effects. Both basal and stimulated acid o...

Failure of ranitidine to interact with propranolol The histamine H2-receptor antagonist ranitidine has recently been introduced into clinical practice for the treatment of peptic ulcer. Its therapeutic effects appear similar to those of cimetidine, but early reports suggest that it does not affect hepatic drug metabolism.' 2 This probably reflects a change in chemical structure, in that the cen...

Antisecretory effect of single oral therapeutic doses of pirenzepine (25 mg and 50 mg) and cimetidine (200 mg and 400 mg) was studied in 12 patients with duodenal ulcer. Gastric secretion was studied in basal condition and after stimulation with pentagastrin. Basal, maximum and peak acid output, basal and maximum acidity, and basal and maximum volume were calculated after computerised correctio...

One hundred patients with endoscopically confirmed duodenal ulcer were treated with cimetidine (Tagamet) in dosage of 1G/day or 400 mg b.d. for six weeks and 400 mg nocte for further 6 weeks. Eighty-five patients completed twelve weeks of cimetidine treatment. Eighty (94%) of these were symptom free and ulcers healed at the end of 12 weeks treatment; fifteen patients were lost to follow up. One...