BACKGROUND Ciclesonide is a novel inhaled corticosteroid for the treatment of airway inflammation. In this study we investigated uptake and in vitro metabolism of ciclesonide in human alveolar type II epithelial cells (A549). Ciclesonide uptake was compared with fluticasone propionate, an inhaled corticosteroid that is not metabolized in lung tissue. A549 cells were incubated with 2 x 10(-8) M ...

BACKGROUND Ciclesonide (CIC) is an effective inhaled corticosteroid for treating asthmatic children. However, its effect on airway inflammation assessed by the fraction of exhaled nitric oxide (FENO) in children with persistent asthma is virtually unknown. We aimed to assess the effect of once-daily generic CIC, 80 or 160 μg, on FENO, lung function, asthma control and bronchial hyperresponsiven...

La reforma del Libro VI CIC, sin abandonar la eclesiología de comunión que inspiró el CIC 1983, ha incorporado algunos principios e institutos tomados Código Pío-Benedictino. El nuevo realza uso ius coactivum Iglesia como instrumento caridad en gobierno.

The growing number of Internet users and the prevalence web applications make it necessary to deal with very complex software in network. This results an increasing new vulnerabilities systems, leading increase cyber threats and, particular, zero-day attacks. cost generating appropriate signatures for these attacks is a potential motive using machine learning-based methodologies. Although there...

We present a framework based on the Calculus of Inductive Constructions (CIC) and its associated tool the Coq proof assistant to allow certification of model transformations in the context of Model-Driven Engineering (MDE). The approached is based on a semi-automatic translation process from metamodels, models and transformations of the MDE technical space into types, propositions and functions...

Author(s): Laurie J. Conway, RN, MS, CIC; Monika Pogorzelska, PhD, MPH; Elaine L. Larson, PhD, RN, FAAN, CIC; Patricia W. Stone, PhD, RN, FAAN Reviewed work(s): Source: Infection Control and Hospital Epidemiology, Vol. 33, No. 6 (June 2012), pp. 640-641 Published by: The University of Chicago Press on behalf of The Society for Healthcare Epidemiology of America Stable URL: http://www.jstor.org/...

UNLABELLED BACKGROUND The presence of basidiomycetous (BM) fungi in induced sputum is an important clinical finding in chronic idiopathic cough (CIC). However, the efficacy of anti-fungal therapy for CIC has not been evaluated. METHODS We selected 10 patients with CIC and carried out allergological examinations for Bjerkandera adusta, a BM fungus that has been shown to enhance cough severi...

Introduction With the general support of the CIC members, the University of Michigan and the University of Illinois at Urbana-Champaign have been working together to share ideas and accomplishments of their institutional repositories (IR) – Deep Blue and IDEALS. Their collaborative goals include creating interoperable systems and learning from one another’s mistakes and successes. They hope lat...

1 Centre de Neuro-imagerie de Recherche (CENIR) de l’Institut du Cerveau et de la Moëlle Epiniere (ICM), Paris, France 2 Inserm U975, CNRS UMR 7225, Université Pierre et Marie Curie Paris6, UMR S975, Centre de Recherche de l’Institut du Cerveau et de la Moëlle épinière, (CR-ICM), Paris, France 3 AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Département de Neurologie, Paris, France 4 CIC Pitié Ne...

Practice Providers Work While Sick Julia E. Szymczak, PhD; Sarah Smathers, MPH, CIC; Cindy Hoegg, BSN, RN, CIC; Sarah B. Klieger, MPH; Julia Shaklee Sammons, MD, MSCE; Division of Infectious Diseases, Center for Pediatric Clinical Effectiveness, The Children’s Hospital of Philadelphia, Philadelphia, PA; Division of Infection Prevention and Control, The Children’s Hospital of Philadelphia, Phila...