objective(s):according to the prevalence of neoplastic diseases, there is a deep necessity for discovery of novel anticancer drugs in the field of medicinal chemistry. in the current study, a new series ofphenylthiazole derivatives(compounds 4a-4f) was synthesizedand theiranticancer activity was assessed in vitro. materials and methods:all synthesized derivatives were evaluated towards three hu...

background and aims. the aim of this study was to evaluate the effect of dilution and curing methods of an etch-and-rinse adhesive and a self-etching primer from the same manufacturer at early exposure time on cytotoxicity of primary hu-man gingival fibroblasts. materials and methods. primary human gingival fibroblasts were exposed to different dilutions of adper single bond (asb) and adper pro...

b ackgro un d : the antimicrobial activity of silver nanoparticles has been investigated in medical fields in recent years, but there are few studies regarding its effect on oral microorganisms. the aim of the present study was to evaluate the in vitro antimicrobial and toxicity properties of nanosilver against two dental plaque microorganisms  and human gingival fibroblast (hgf) cell line. me ...

objective(s): the aim of this study was to determine cytotoxic effect of nanoliposomal form of lyophilized aqueous extract of ecballium elaterium fruit on gastric cell line (ags) using cell viability tests. methods: an aqueous extract of the fruits of ecballium elaterium was prepared. nanoliposomal form was also prepared by thin-film hydration method and stability size was determined by sem. th...

New Zealand propolis is a "European" type propolis obtained by honey bees mainly from exudates of poplar. European type propolis is known to have anti-inflammatory and anti-cancer properties and this activity has been attributed to some of the main constituents such as chrysin and CAPE (caffeic acid phenethyl ester). As part of our studies on how New Zealand propolis might benefit gastro-intest...

Bu çalışma kurşun asetat (PbA) kaynaklı karaciğer hasarı üzerine chrysinin (CH) etkilerinin araştırılması amacıyla yapıldı. Çalışmada 35 adet Sprague Dawley cinsi erkek rat, her grupta 7 rat olacak şekilde 5 gruba ayrıldı. 1. Grup (Kontrol): Oral yolla serum fizyolojik verildi. 2. (CH grubu): CH (50 mg kg-1 ağırlık gün-1) gün boyunca oral olarak ratlara 3. (PbA PbA (30 kg-1) 30 4. (PbA+CH 25 mg...

this study aimed to evaluate the cellular toxicity of two newly-released acrylic resins (futura gen and gc reline hard) in comparison with the conventional heat-cure resin (meliodent).sample discs from each acrylic resin were placed in 24-well culture plates along with l929 mouse fibroblast cell line. a mixture of the rpmi 1640 medium, antibiotics and 10% fbs was added to the plates and the spe...