نتایج جستجو برای: chronotropic
تعداد نتایج: 1590 فیلتر نتایج به سال:
BACKGROUND It has been reported that edrophonium can antagonize the negative chronotropic effect of carbachol. This study was undertaken to evaluate in detail the interaction of edrophonium with muscarinic Mz and M3 receptors. METHODS A functional study was conducted to evaluate the effects of edrophonium on the concentration-response curves for the negative chronotropic effect and the bronch...
AIMS Given the clinical interest concerning 'reflex vagal' responses to identify left atrial (LA) targets for ablative therapy of atrial fibrillation, we investigated whether vagal and bilateral atrial neural pathways may be involved in chronotropic and atrial repolarization responses to LA ganglionated plexus (GP) stimulation. METHODS AND RESULTS Unipolar electrograms were recorded from 191 ...
We determined the effects of the timing of repetitive bursts of vagal stimulation on the positive chronotropic responses of the heart to trains of cardiac sympathetic nerve stimulation in open-chest anesthetized dogs. Trains of sympathetic stimulation alone, at frequencies of 2 and 4 Hz, decreased the cardiac cycle length by 176 +/- 19 msec (mean +/- SE) and 190 +/- 22 msec, respectively. When ...
Angiotensin (Ang) II has two major receptor isoforms, AT1 and AT2. Currently, AT1 antagonists are undergoing clinical trials in patients with cardiovascular diseases. Treatment with AT1 antagonists causes elevation of plasma Ang II which selectively binds to AT2 and exerts as yet undefined effects. Cardiac AT2 level is low in adult hearts, whereas its distribution ratio is increased during card...
A constant pressure perfusion of the sinus node artery was performed in ten vagotomized dogs. The selective administration of adenosine, AMP, ADP or ATP into this artery caused a negative chronotropic effect which was not blocked by either atropine or tetrodotoxin, but was blocked by the continuous infusion of caffeine or theophylline. In the meanwhile atrial fibrillation was readily induced by...
Fingolimod (Gilenya) is a new oral drug for treatment of multiple sclerosis in adults (1). It is known that fingolimod therapy commonly carries adverse reactions such as a negative chronotropic effect and an increased atrioventricular conduction time in adolescents and adults (2). However, the drug is not used in children and reports describing the consequences of fingolimod in overdose are ext...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید