Vitiligo is a chronic skin condition which affects 0,5-2% of the world’s population, without any sex or ethnical predilection. Clinically it characterized by development well-defined depigmented macules. Although its etiopathogenesis exquisitely compound and remains not fully anderstood, known that results from destruction melanocytes present in skin. The aim this paper to vitiligo clinical pic...

Granulomatosis with polyangiitis (GPA), formerly known as Wegener’s granulomatosis, is a rare immunological small vessel disease which usually affects respiratory tract and kidneys. However, salivary gland involvement in GPA primary manifestation. We report case of the presentation submandibular involvement. A 48-year-old female patient presented swelling skin defect that lasted for 1 month. Al...

BACKGROUND Accumulation of advanced glycation end-products (AGEs) has been implicated in the pathogenesis of chronic transplant dysfunction and cardiovascular disease in renal transplant recipients. We aimed to investigate which factors are associated with tissue AGE accumulation in renal transplant recipients. METHODS The AGE accumulation was assessed using a validated skin-autofluorescence ...

the bicuspid aortic valve is known to be the most common congenital cardiac malformation, with an approximate incidence rate of 1-2% in the general population. most patients are unaware of the disease until the onset of infective endocarditis, which is a life-threatening complication that may affect a heart valve or other cardiac structures at the site of endothelial damage. a 22-year-old man p...

chronic granulomatous disease (cgd), a rare inherited primary immunodeficiency disorder,  is  caused  by  mutation  in  any  one  of  the  genes  encoding  components   of nicotinamide adenine dinucleotide phosphate (nadph)-oxidase enzyme. ncf2 gene (encoding p67-phox component) is one of them and its mutation is less common to cause cgd (around 5-6%). here, we assessed mutation analysis of ncf...

abstract background: quality of life is a concept, which in recent years is considered as a measure for health in chronic diseases such as kidney diseases. complications of chronic diseases can affect the quality of life in children and their families over time. therefore, empowerment programs are necessary to improve their quality of life. this study aimed to investigate the impact of the fami...

background: mustard gas has different effects on different body systems such as respiratory tract, blood, gastrointestinal, skin, eye, endocrine and peripheral nervous system. objectives: the purpose of this study was to determine the quality of life in chemical warfare veterans due to sulfur mustard exposure. patients and methods: in a cross-sectional and analytic study, 242 patients who had a...

background and objective: endocrine disorders are common in patients with chronic kidney disease (ckd). the aim of the present study is reviewing available literature to give a deep understanding of complexities of endocrine disorders in chronic kidney disease. methods: a narrative reviewing method based on the available literature was approached. findings: generally, when renal function decrea...

abstract objectives: interruption of rennin-angiotensin-aldosterone system has become a leading therapeutic strategy in the treatment of diabetic nephropathy however, aceis and arbs do not uniformly suppress the rennin-angiotensin-aldosterone system. plasma aldosterone levels are elevated in a group of patients despite therapy and this phenomenon known as aldosterone escape or aldosterone break...

INTRODUCTION The basophil activation test showing CD63 up regulation could be a specific and sensitive in vitro complementary text to the in vivo autologous serum skin test for the activity assessment of the patients suffering autoimmune chronic spontaneous urticaria. The aim of this study is to define the basophil activation test as a useful tool in clinical practice in order to identify those...