People with chronic musculoskeletal pain often experience pain-related fear of movement and avoidance behavior. The Fear-Avoidance model proposes a possible mechanism at least partly explaining the development and maintenance of chronic pain. People who interpret pain during movement as being potentially harmful to the organism may initiate a vicious behavioral cycle by generating pain-related ...

OBJECTIVES To present the prevalence of self reported musculoskeletal diseases, the coexistence of these diseases, the test-retest reliability with six months in between, and the association with musculoskeletal pain symptoms. METHODS Twelve layman descriptions of common musculoskeletal diseases were part of the questionnaires of a prospective cohort study of a random sample in the general Du...

INTRODUCTION Brain-derived neurotrophic factor (BDNF) disturbances and life stress, both independently and in interaction, have been hypothesized to induce chronic pain. We examined whether (a) the BDNF pathway (val(66)met genotype, gene expression, and serum levels), (b) early and recent life stress, and (c) their interaction are associated with the presence and severity of chronic multi-site ...

Acute pain is the most common symptom for which patients seek medical care. Chronic pain is severe and frequent health care problem in terms of patient suffering and economic implications for the society. More than half of chronic pain related to musculoskeletal pain. Epidemiological studies on pain are limited by inconsistencies in definition, identification, and evaluation. The reported preva...

[Purpose] Primary care is considered the gateway to the Brazilian public health system and is responsible for managing the most prevalent problems in the population. In this study, the effects of Back School on pain, functionality, and the performance of activities of daily living (ADL) in users with chronic musculoskeletal pain were evaluated. [Subjects and Methods] Forty-four users (33 female...

OBJECTIVES This systematic review and meta-analysis examined the effects of psychological therapies for management of chronic pain in children.  METHODS Randomized controlled trials of psychological interventions treating children (<18 years) with chronic pain conditions including headache, abdominal, musculoskeletal, or neuropathic pain were searched for. Pain symptoms, disability, depressio...

Purpose: Following musculoskeletal trauma, a high proportion of people develop chronic pain, irrespective the severity injury. Central sensitisation (CS) characterised by features such as secondary hyperalgesia, tactile allodynia and widespread could offer an explanation to transition from acute pain. No study has evaluated early CS in this population. This exploratory aimed investigate CS, alo...

Chronic musculoskeletal pain is debilitating and affects ∼ 20% of adults. Tissue acidosis is present in painful musculoskeletal diseases like rheumatoid arthritis. ASICs are located on skeletal muscle and joint nociceptors as well as on nonneuronal cells in the muscles and joints, where they mediate nociception. This review discusses the properties of different types of ASICs, factors affecting...

Low back pain is the most frequent musculoskeletal complaint worldwide and leading cause of chronic disability. In this review we discuss knowledge about the role of management of non-invasive, conservative therapy for the nonspecific low back pain. Initial therapy includes modification of activity, pharmacological analgesic therapy and education of patients. In patients with sub acute or chron...