Although the underlying molecular causes of aging are not entirely clear, hormetic agents like exercise, heat, and calorie restriction may generate a mild pro-oxidant stress that induces cell protective responses to promote healthy aging. As an individual ages, many cellular and physiological processes decline, including wound healing and reparative angiogenesis. This is particularly critical i...

In this research, the response of shoot and root of two cultivars of soybean (Glycine max L. cvs Gorgan 3 & Williams) to mild and severe drought was evaluated in pot. Two weeks after of planting, three irrigation treatments including every day (as control), once in three (as mild stress) and five days (as severe stress) were used. The results showed that, stem dry weight, stem and root length, ...

Chronic stress which can cause a variety of disorders and illness ranging from metabolic and cardiovascular to mental leads to alterations in content, structure and dynamics of biomolecules in brain. The determination of stress-induced changes along with the effects of antidepressant treatment on these parameters might bring about more effective therapeutic strategies. In the present study, we ...

Background: Recently, some shocking epidemics of chronic kidney disease of undetermined origin have been reported. In this regard, numerous lines of evidence suggest that socioeconomic and environmental stressors have a key role, an effect that needs further confirmation. The present study was undertaken to explore the effect of Chronic Unpredictable Stress (CUS) on kidney function and structur...

BACKGROUND/AIMS Chronic stress can lead to cognitive impairment. Senescence-accelerated mouse prone 8 (SAMP8) is a naturally occurring animal model that is useful for investigating the neurological mechanisms of Alzheimer's disease. Here we investigated the impact and mechanisms of chronic stress on cognition in male SAMP8 mice. METHODS Male 6-month- old SAMP8 and SAMR1 (senescence-accelerate...

There is accumulating evidence that adult neurogenesis and dendritic plasticity in the hippocampus are neuroplastic phenomena, highly sensitive to the effects of chronic stress and treatment with most classes of antidepressant drugs, being involved in the onset and recovery from depression. However, the effects of antidepressants that act through the selective inhibition of monoamine oxidase su...

BACKGROUND Although alterations in not only the pain sensitivity but also the analgesic effects of opioids have been reported under conditions of stress, the influence of unpredictable chronic mild stress (UCMS) on the antinociceptive effects of opioid analgesics remains to be fully investigated. The present study examined the influence of UCMS on the thermal pain sensitivity and antinociceptiv...

Introduction: Stress is a main factor influencing brain functions as revealed by the electroencephalogram (EEG) recordings. Moreover, different stress durations seemingly cause perturbations in brain waves and lead to mental disorders. This study investigates the effects of acute, sub-chronic and chronic stress on EEG in rats.  Methods: Twenty-eight Wistar adult male rats were randomly all...