The diverse genetic backgrounds of lupus-prone murine models, which produce both quantitative and qualitative differences in disease expression, may be a valuable resource for studying the influence of environmental exposure on autoimmune disease in sensitive populations. We tested this premise by exposing autoimmune-prone BXSB and the nonautoimmune C57BL/6 mice to the heavy metal mercury. Alth...

Mercury is neurotoxic, and numerous studies have confirmed its ototoxic effect. However, the diagnosis and follow-up of mercury exposure require understanding the pathophysiology of the chemical substance. Based on a systematic literature review, this study aimed to demonstrate whether mercury is ototoxic and to analyze its mechanism of action on the peripheral and central auditory system, in o...

This study investigated the effects of increasing mercury (Hg) concentration on early developmental stages of sea urchin, Echinomethra mathaei, as a bioindicator. The toxicity test was carried out after the gamete released induction and fertilization in six concentrations of mercury within the range of 4, 8, 16, 32, 64 and 128 µg/L. Embryos samples were incubated for 30 h in control and test so...

Lead (Pb) and methyl mercury (MeHg) are well established neurodevelopmental toxicants (NDTs), but joint exposure to chemical and nonchemical (e.g., maternal stress) stressors has rarely been considered. We characterized exposure to Pb, MeHg and a measure of physiological dysregulation associated with chronic stress and examined race/ethnicity as a predictor of joint NDT exposure. Using data fro...

The estimated average daily employment in the Indian mining sector is 5,60,000, which comprises 87% in the public sector and 13% in the private sector, of which around 70,000 are working in metallic mines. The mine workers are exposed to dust of various potentially toxic substances. The common toxicants present in the mining environment are lead, mercury, cadmium, manganese, aluminium, fluoride...

Effect of mercury on blood and its components of fish Labeo rohita was carried out in this study. The LC50 dose of 57.074 mg/L and mercuric chloride exposure for 96 h resulted in significant changes in the physico-chemical properties such as hemoglobin, osmotic fragility and blood cell counts. Further, mercury exposure also caused a considerable reduction in the sulf-hydryl group of glutathione...

abstract background and objective: there have been concerns over possible association between mercury and neurodevelopmental outcomes in infants. in this study we aimed to determine whether blood levels of mercury are above safe values in iranian infants or not. materials and methods:  a total of 85 infants (0, 2, 4 and 6 months old) were enrolled in this study. all of them received vaccines ac...

The findings come from a nine-year University of Rochester study conducted in the Republic of the Seychelles, an island nation in the Indian Ocean where most people eat nearly a dozen fish meals each week and whose mercury levels are about 10 times higher than most U.S. citizens. Indeed, no harmful effects were seen in children at levels up to 20 times the average U.S. level. The work is publis...

BACKGROUND Mercury is a persistent, biomagnifying contaminant that can cause negative effects on ecosystems. Marshes are often areas of relatively high mercury methylation and bioaccumulation. Nelson's Sparrows (Ammodramus nelsoni) use marsh habitats year-round and have been documented to exhibit tissue mercury concentrations that exceed negative effects thresholds. We sought to further charact...

Data on mercury and selenium interaction in the mammalian body are reviewed. Experimental data from studies on rats show that selenium interacts with mercury metabolism and toxicity after exposure to mercuric mercury. Autopsy data from workers exposed to mercury vapor indicate an association between mercury and selenium retention in the central nervous system, suggesting the formation of a merc...