PurposeCLAD, the main limitation to long-term survival after a lung transplantation (LTx), has two phenotypes: bronchiolitis obliterans syndrome (BOS) and restrictive allograft (RAS). There is great need for better characterization of cells within tissue. We aimed assess CLAD allografts using imaging mass cytometry (IMC), high dimensional tissue system allowing comprehensive multiparametric in ...

Remarkable progress has been made with respect to cardiac transplantation over the past 3 decades.1 Few dramas are as compelling as a successful heart transplant in a patient who otherwise would die of cardiogenic shock. Improved outcomes relate to our greater (but yet incomplete) insight into the pathophysiology of allograft rejection. Still, the transplanted heart is not normal, and it is sub...

: The long-term survival after lung transplantation (LT) is favorable in Japan. However, survivors LT are subject to late complications, including chronic allograft dysfunction (CLAD), malignancy, infection, and kidney disease (CKD) because of the need for lifelong immunosuppression. rates single cadaveric (CLT) living-donor lobar (LDLLT) higher than that bilateral CLT Here, we will describe ma...

the relation between microchimerism and allograft tolerance is still a mystery. in this study we determined the presence of peripheral blood microchimerism (pbmc) in female renal transplant recipients from living male donors with second round polymerase chain reaction (pcr). second round pcr was used to find y chromocome products. the degree of pbmc in renal transplant recipinents must be below...

BACKGROUND Lung function is altered by infection and rejection in patients who undergo heart-lung transplantation. The sensitivity, specificity, and positive/negative predictive values (PPV and NPV) of lung function for the detection of allograft dysfunction in these patients were measured. METHODS Thirty three patients who underwent heart-lung transplantation were followed for a mean period ...

PurposeLung transplant (LTx) is limited by a supply of donor lungs. Donor lungs from smokers are known to have adverse effects on early post-LTx outcomes (Oto et al, 2004). As long-term survival remains under assessed we investigated the effect smoking LTx and death chronic lung allograft dysfunction (CLAD) using cohort described Oto al.Methods173 bilateral recipient records between 1995-2002 w...

PurposeLung transplantation outcomes are limited by chronic lung allograft dysfunction (CLAD). Infection driven loss of graft function is a common cause CLAD. Extracorporeal photopheresis (ECP) salvage therapy post with the indications broadening as experience and availability increases. The therapeutic role ECP yet to be explored in infection CLAD.MethodsA retrospective audit all transplant re...

Tremendous progress has been made in the field of transplantation with significant improvement in preventing acute rejection that has resulted in improved graft survival. However long term graft survival still remains limited due to chronic allograft rejection. Chronic rejection is a major impediment for long-term graft function and its incidence is almost universal especially following human l...