Inflammation is one of the major health threats to humans, and it associated with various chronic diseases, including metabolic syndrome, type 2 diabetes, cardiovascular several types cancer. For example, colonic inflammation can result in damage intestinal barrier, as indicated by invasion immune cells reduced tight junctions. Inflammatory responses also lead erythema edema on skin. The interv...

Chronic obstructive pulmonary disease (COPD) is a common chronic airway inflammatory disease. With its heterogeneity in clinical manifestations, treatment responses and prognosis, biomarkers that can predict benefits risk stratification of deterioration are very important. In recent years, many studies have reported eosinophils highly involved the development inflammation COPD. The baseline blo...

Background and Aims: Chronic inflammation is a hallmark of atherosclerosis results from an imbalance between pro-inflammatory pro-resolving signaling. The human GPR32 receptor serves in tandem with the ALX/FPR2 to transduce biological actions mediators that stimulate resolution inflammation. However, since no murine homologs exist comprehensive vivo studies are lacking, we generated novel trans...

Chronic inflammation is a major risk factor underlying aging and the associated diseases of aging; of particular interest is insulin resistance during aging. Chronic inflammation impairs normal lipid accumulation, adipose tissue function, mitochondrial function, and causes endoplasmic reticulum (ER) stress, which lead to insulin resistance. However, some studies show that insulin resistance its...

Alzheimer, a chronic neurodegenerative disease, usually starts slowly and worsens gradually. It causes 60% to 70% of dementia cases. Difficulty in remembering recent events (short-term memory loss) is the most prominent early symptom. As the disease progresses, patients may have problems such as impaired language, disorientation (including easily getting lost), mood swings, loss of motivation, ...

background helicobacter pylori is responsible for one of the most common human infections and is a major risk factor for stomach ulcer disease and gastric cancer. h. pylori infection has been reported to be associated with generation and development of coronary artery disease (cad). moreover, diabetic patients positive for h. pylori infection showed a higher prevalence of cad compared to h. pyl...

Patients with psoriasis have systemic and vascular inflammation and are at increased risk for myocardial infarction, stroke, and cardiovascular death. However, the underlying mechanism(s) mediating the link between psoriasis and vascular disease is incompletely defined. This study sought to determine whether chronic skin-specific inflammation has the capacity to promote vascular inflammation an...

PURPOSE OF REVIEW This article describes the background, clinical presentation, diagnosis, and treatment of selected etiologies of subacute and chronic meningitis. Key diagnostic considerations when evaluating a patient presenting with chronic inflammation of the CNS are discussed, and several specific infectious, neoplastic, and autoimmune etiologies are reviewed in detail. RECENT FINDINGS W...