نتایج جستجو برای: chronic dermal toxicity

تعداد نتایج: 622190  

Journal: :The Journal of clinical investigation 1999
A Le Moine V Flamand F X Demoor J C Noël M Surquin R Kiss M A Nahori M Pretolani M Goldman D Abramowicz

C57BL/6 mice injected with the 145-2C11 anti-CD3 mAb and grafted with MHC class II disparate bm12 skin develop a chronic rejection characterized by interstitial dermal fibrosis, a marked eosinophil infiltrate, and an obliterative intimal vasculopathy. Because these changes occur in the absence of alloreactive antibodies, we examined the contribution of cytokines in their pathogenesis. Chronical...

2013
Mitra Korani Seyed Mahdi Rezayat Sepideh Arbabi Bidgoli

Silver nanoparticles (Ag NPs) have been widely used as new potent antimicrobial agents in cosmetic and hygienic products. Present study compares the tissue levels of Ag NPs in different organs of Guiana Pigs quantitatively after dermal application and analysis the morphological changes and pathological abnormalities on the basis of the Ag NPs tissue levels. Before toxicological assessments,the ...

Journal: :Environment international 2015
Mohamed Abou-Elwafa Abdallah Gopal Pawar Stuart Harrad

Ethical and technical difficulties inherent to studies in human tissues are impeding assessment of the dermal bioavailability of brominated flame retardants (BFRs). This is further complicated by increasing restrictions on the use of animals in toxicity testing, and the uncertainties associated with extrapolating data from animal studies to humans due to inter-species variations. To overcome th...

Journal: :Foot & ankle international 2010
Jay H Rapley John Crates Alan Barber

BACKGROUND This study evaluated an acellular dermal matrix allograft augmentation for chronic mid-substance peroneous longus and brevis tendon tears. The hypothesis was that acellular dermal matrix allograft augmentation of chronic longitudinal mid-substance or complete tears of both peroneal tendons provides sufficient initial strength to allow a rapid rehabilitation program. MATERIALS AND M...

2013

Human toxicity Elemental selenium metal has a relatively low order of toxicity. Acute poisoning with selenium and its salts are rare, however, in excessive amount toxic and even fatal action was documented. Normal whole blood selenium levels in adults range from 0.085 to 0.13 mg/l [2]. All selenium salts can produce toxicity by ingestion, inhalation, and percutaneous absorption, although specif...

2014
P. Gorayski M. B. Pinkham J. B. Muir A. P. Pullar

Argyria is a rare cutaneous condition due to dermal silver deposition leading to irreversible blue-grey discoloration. Acute radiation dermatitis (RD) is an expected toxicity in patients undergoing radiotherapy but it is unknown to what extent argyria affects the onset and severity of RD. We report a patient with argyria treated with concurrent chemoradiotherapy for Merkel cell carcinoma who ex...

2013
Elena García-Gareta Nivedita Ravindran Vaibhav Sharma Sorousheh Samizadeh Julian F. Dye

The clinical demand for effective dermal substitutes continues as current commercially available products present limitations. However, there are no definitive in vitro methods to predict in vivo outcomes such as integration, cellularization and contraction, which may help the development of new dermal scaffolds. This study aimed to develop a multiparameter in vitro model of three-dimensional (...

2018
Yong Mao Anya Singh-Varma Tyler Hoffman Sandeep Dhall Alla Danilkovitch Joachim Kohn

Biofilm, a community of bacteria, is tolerant to antimicrobial agents and ubiquitous in chronic wounds. In a chronic DFU (Diabetic Foot Ulcers) clinical trial, the use of a human cryopreserved viable amniotic membrane (CVAM) resulted in a high rate of wound closure and reduction of wound-related infections. Our previous study demonstrated that CVAM possesses intrinsic antimicrobial activity aga...

2007
S. K. Rastogi C. Kesavachandran Farzana Mahdi Amit Pandey

Phthalates are used in commercial products as softners of plastics, solvents in perfumes and additives to hair sprays, lubricants and insect repellents. The wide spread use of phthalate results in multiple human exposure routes i.e., ingestion, inhalation and dermal exposure. In the present review, a detailed account of respiratory toxicity, phthaltes is high given their use in a vast range of ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید