Kluyveromyces lactis hAT-transposase 1 (Kat1) generates hairpin-capped DNA double strand breaks leading to MAT-switching (MATa to MATα). Using purified Kat1, we demonstrate the importance of terminal inverted repeats and subterminal repeats for its endonuclease activity. Kat1 promoted joining of the transposon end into a target DNA molecule in vitro, a biochemical feature that ties Kat1 to tran...

In this paper, at first, a 24/16 three-phase switched reluctance motor is designed, then the rotor poles shape tips corrected for reduction ripple of single-phase torque waveform. By doing this, the single-phase torque waveform has a flat surface and consequently, the single-phase torque ripple is reduced. Also, due to the commutation between the machine phases, the torque drops during this tim...

In ground based infrared imaging a well-known technique to reduce the influence of thermal and background noise is chopping and nodding, where four different signals of the same object are recorded from which the object is reconstructed numerically. Since noise in the data can severely affect the reconstruction, regularization algorithms have to be implemented. In this paper we propose to combi...

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BACKGROUND Bone marrow adipose tissue (MAT) contributes to increased circulating adiponectin, an insulin-sensitizing hormone, during caloric restriction (CR), but whether this occurs in other contexts remains unknown. The antidiabetic thiazolidinediones (TZDs) also promote MAT expansion and hyperadiponectinemia, even without increasing adiponectin expression in white adipose tissue (WAT). OBJ...

BACKGROUND Osteochondral allograft transplantation (OCA) is often performed with concomitant meniscus allograft transplantation (MAT) as a strategy for knee joint preservation, although to date, the effect of concomitant MAT on outcomes and failure rates after OCA has not been assessed. PURPOSE To determine clinical outcomes for patients undergoing OCA with MAT as compared with a matched coho...

Despite association with low bone density and skeletal fractures, marrow adipose tissue (MAT) remains poorly understood. The marrow adipocyte originates from the mesenchymal stem cell (MSC) pool that also gives rise to osteoblasts, chondrocytes, and myocytes, among other cell types. To date, the presence of MAT has been attributed to preferential biasing of MSC into the adipocyte rather than os...