نتایج جستجو برای: cholinergic neurons

تعداد نتایج: 183366  

2014
Yui Yamamoto Kohji Fukunaga

Olfactory bulbectomy (OBX) causes cognitive dysfunction by degeneration of cholinergic neurons in the medial septum. Here, we define an involvement of nicotinic acetylcholine receptor (nAChR) in neuroprotective effect of donepezil in the septum neurons of OBX mice. Neuroprotective effects on the medial septal cholinergic neurons were assessed after chronic donepezil administration in OBX mice. ...

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Journal: :Journal of Neurophysiology 2008

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Journal: :Mechanisms of Development 1997
U Ernsberger H Patzke H Rohrer

Cholinergic properties in chick sympathetic neurons are detectable early during development of paravertebral ganglia and mature after target contact. The cholinergic marker choline acetyltransferase (ChAT) is first detectable at embryonic day 6 and its expression partly overlaps with that of the noradrenergic marker tyrosine hydroxylase (TH). At late embryonic stages, when sympathetic neurons h...

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Journal: :Neuron 2016
Salvatore J. Cherra Yishi Jin

Synaptic maintenance is essential for neural circuit function. In the C. elegans locomotor circuit, motor neurons are in direct contact with the epidermis. Here, we reveal a novel epidermal-neuronal interaction mediated by a two-immunoglobulin domain transmembrane protein, ZIG-10, that is necessary for maintaining cholinergic synapse density. ZIG-10 is localized at the cell surface of epidermis...

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2009
JULIO VILLALOBOS VLADIMIR SALDARRIAGA

The anatomical organization of the basal forebrain cholinergic system with emphasis on the basal magnocellular nucleus, was studied by means of the choline acetyltransferase immunohistochemistry. The basal forebrain cholinergic system extends from the medial septum to the caudal part of the globus pallidus, and is organized as a continuous valley of cholinergic neurons. The arrangement of choli...

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Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1983
E Wolinsky P H Patterson

Establishment of transmitter phenotype is an essential step in neuronal development. Studies on rat sympathetic neurons both in vivo and in vitro have provided evidence that mature cholinergic sympathetic neurons arise from previously noradrenergic neurons. Cultured rat superior cervical ganglion neurons can be influenced by their environment to remain noradrenergic, to acquire dual transmitter...

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2017
Christiane Jungen Katharina Scherschel Christian Eickholt Pawel Kuklik Niklas Klatt Nadja Bork Tim Salzbrunn Fares Alken Stephan Angendohr Christiane Klene Janos Mester Nikolaj Klöcker Marieke W Veldkamp Udo Schumacher Stephan Willems Viacheslav O Nikolaev Christian Meyer

The parasympathetic nervous system plays an important role in the pathophysiology of atrial fibrillation. Catheter ablation, a minimally invasive procedure deactivating abnormal firing cardiac tissue, is increasingly becoming the therapy of choice for atrial fibrillation. This is inevitably associated with the obliteration of cardiac cholinergic neurons. However, the impact on ventricular elect...

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Journal: The Iranian Journal of Pharmaceutical Research 2010
A Sarkaki AV Amari SM Zarei SMT Mansouri

Previous studies have shown that paragigantocellularis nucleus (PGI) neurons contain some neurotransmitters such as GABA, neuropeptides, monoamines, substance P, enkephalin and serotonin. It has been suggested that PGI is a main cholinergic source in the rat’s brain stem. There are few evidences on the presence and importance of cholinergic receptors on PGI neurons with regard to nociception. I...

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Journal: :Alzheimers & Dementia 2023

Background Cholinergic innervation is affected in multiple neurodegenerative diseases associated with cognitive dysfunction. Loss of cholinergic neurons Alzheimer’s disease (AD) correlated impairment. Nerve growth factor (NGF) plays a major role the maintenance and function neurons. The activation NGF-induced trophic signaling via TrkA could be promising therapy for including AD. E2511 novel sm...

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Journal: :Alzheimers & Dementia 2023

Background Cholinergic innervation is particularly vulnerable in many neurodegenerative diseases associated with cognitive dysfunction, and loss of cholinergic neurons Alzheimer’s disease (AD) pathogenic event observed from early stage correlated impairment. Nerve growth factor (NGF) plays a major role the maintenance function neurons, decrease trophic signalling by NGF-Tropomyosin receptor kin...

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