In intact urethane-anesthetized rats, plasma growth hormone (GH) levels were low but increased significantly following intravenous injection of chlorpromazine. Plasma GH levels were significantly elevated in rats with hypothalamic cuts such as complete deafferentiation, anterior cut and antero-lateral cut, whereas plasma GH levels in rats with posterior cut or postero-lateral cut were not sig...

BACKGROUND This is the first report testing the antibiotic resistance-modifying activity of Mentha arvensis against MRSA (methicillin-resistant Staphylococcus aureus). MATERIALS AND METHODS In this study an ethanol extract of Mentha arvensis L. and chlorpromazine were tested for their antimicrobial activity alone or in combination with conventional antibiotics against MRSA strains. RESULTS ...

Chlorpromazine hydrochloride, a synthetic phenothiazine, has been widely employed in psychiatric illnesses, and an extensive literature exists on its side-effects; many reports describe ocular changes, including an oculo-dermal melanosis with deposition of pigment in the retina (Feldman and Frierson, I964; Zelickson and Zeller, I964; Cairns, Capoore, and Gregory, I965; Brit. med. J., I967), dep...

Ebola virus (EBOV) infects several cell types and while viral entry is known to be pH-dependent, the exact entry pathway(s) remains unknown. To gain insights into EBOV entry, the role of several inhibitors of clathrin-mediated endocytosis in blocking infection mediated by HIV pseudotyped with the EBOV envelope glycoprotein (EbGP) was examined. Wild type HIV and envelope-minus HIV pseudotyped wi...

Chlorpromazine, a phenothiazine antipsychotic, is an old generation major tranquilizer that has remained relevant in the management of psychosis despite the advent of the newer atypical brands. Priapism, an uncommon urological condition may result from the alphaadrenergic blocking action of antipsychotics. A 46 years old man developed priapism in the course of treatment with chlorpromazine. He ...

OBJECTIVE To study the impact of obesity on postoperative morbidity and outcome following surgical resection of primary oesophageal adenocarcinoma (EADC). METHODS From a prospective database, we compared clinicopathological findings (age, gender, surgical approach, tumour differentiation and stage), postoperative mortality, morbidity, length of hospitalisation, disease-free survival (DFS) and...

Biological uranium reduction was investigated using bacteria isolated from a uranium mine in Limpopo, South Africa. Background uranium concentration in soil from the mine was determined to be 168 mgkg(-1) much higher than the typical background uranium concentration in natural soils (0.30-11.7 mgkg(-1)). Therefore it was expected that the bacteria isolated from the site were resistant to U(VI) ...

AIMS We investigated whether the treatment with anthocyanins prevents the scopolamine-induced memory deficits and whether ectonucleotidase activities and purine levels are altered in the cerebral cortex (CC) and hippocampus (HC) in this model of mnemonic deficit in rats. MAIN METHODS The animals were divided into 4 experimental groups: control (vehicle), anthocyanins (Antho), scopolamine (SCO...

DURING the past decade the drug treatment of psychiatric illness has advanced with remarkable rapidity. The principal drugs concerned are those with predominant actions on higher mental and neurological functions and collectively referred to as psychotropic drugs. The main drugs used in practice can be classified into (i) Anti-psychotic drugs (Neuroleptics). (2) Anti-depression drugs. (3) Anti-...

The roots of 7-d seedlings of two winter wheat cultivars differing in frost resistance were used to study changes in lectin activity using the inhibitor of microtubule polymerization oryzalin (15 μM) in unhardened (23oC) and hardened (2–3oC, 3–7 d) plants. Plants were grown with the antagonist of calmodulin, chlorpromazine (250 μM) or without chlorpromazine in medium. It was shown that the dyna...