The intestinal epithelium demonstrates differential properties, providing both barrier and transport functions with respect to luminal molecules. Intestinal permeability relates to barrier function and, although it is the ‘permeation’ of molecular markers that is used to measure ‘permeability’, the terms are often confused. Permeability is that property of the intestinal epithelium or of a memb...

permeability can be directly measured using cores taken from the reservoir in the laboratory. due to high cost associated with coring, cores are available in a limited number of wells in a field. many empirical models, statistical methods, and intelligent techniques were suggested to predict permeability in un-cored wells from easy-to-obtain and frequent data such as wireline logs. the main obj...

A distinctive feature of the voltage-dependent chloride channels ClC-0 (the Torpedo electroplaque chloride channel) and ClC-1 (the major skeletal muscle chloride channel) is that chloride acts as a ligand to its own channel, regulating channel opening and so controlling the permeation of its own species. We have now studied the permeation of a number of foreign anions through ClC-1 using voltag...

We have used the whole-cell patch clamp recording technique to characterize a swelling-activated chloride current in guinea pig atrial and ventricular myocytes and to compare the electrophysiological and pharmacological properties of this current with the isoprenaline-activated chloride current in the same cell types. Osmotic swelling of guinea pig cardiac myocytes caused activation of an outwa...

The transient increase in cation permeability observed in duck red cells incubated with norepinephrine has been shown to be a linked, bidirectional, co-transport of sodium plus potassium. This pathway, sensitive to loop diuretics such as furosemide, was found to have a [Na + K] stoichiometry of 1:1 under all conditions tested. Net sodium efflux was inhibited by increasing external potassium, an...