ABSTRACTAntioxidants in the ethanolic extract of suji leaves (Pleomele angustifolia) have potential as a sunscreen. The use chitosan nanoparticle system is able to protect degradation flavonoids due influence temperature and light. Tween 80 cetyl alcohol play strategic role formation cream preparations. purpose this study was determine characteristics sunscreen with variations 80-cetyl containi...

BACKGROUND The purpose of this study was to investigate the downregulation of mRNA expression of vascular endothelial growth factor (VEGF) by triamcinolone acetonide acetate (TAA)-loaded chitosan nanoparticles in human retinal pigment epithelial cells. METHODS TAA-loaded deoxycholic acid-modified chitosan (TAA/DA-Chit) nanoparticles were prepared via a self-assembly mechanism, and their morph...

Pancreatic islet transplantation is the only curative, noninvasive treatment for type 1 diabetes mellitus; however, high rates of cell death in the immediate postimplantation period have limited the success of this procedure. Bilirubin, an endogenous antioxidant, can improve the survival of murine pancreatic allografts during hypoxic stress but has poor solubility in aqueous solutions. We hypot...

The nanoparticle drug delivery system, which uses natural or synthetic polymeric material as a carrier to deliver drugs to targeted tissues, has a broad prospect for clinical application for its targeting, slow-release, and biodegradable properties. Here, we used chitosan (CTS) and hepatoma cell-specific binding molecule glycyrrhetinic acid to synthesize glycyrrhetinic acid-modified chitosan (G...

Development of parameters for the fabrication of nanosized vectors is pivotal for its successful administration in therapeutic applications. In this study, homogeneously distributed chitosan nanoparticles (CNPs) with diameters as small as 62 nm and a polydispersity index (PDI) of 0.15 were synthesized and purified using a simple, robust method that was highly reproducible. Nanoparticles were sy...

Many strategies have been developed to improve vaccine delivery in the past decade. The aim of the current study was to develop a nanoparticulate system based on ionic gelation between chitosan and tripolyphosphate in order to load Androctonus Crassicauda scorpion venom. The best formulation was selected according to the highest association efficiency, loading capacity, optimum particle size an...

Objective(s): Chronic hyperglycemia leads to activation of the advanced glycation end products (AGE)-receptor (RAGE) for AGE axis and oxidative stress, which promote diabetic renal damage. This study examines the effect of insulin-loaded trimethyl chitosan nanoparticles on the kidney tissue of diabetic rats. Materials and Methods: Twenty-five male Wistar rats were randomly divided into 5 groups...

Background: The ethanolic extract of Anredera cordifolia (AC) leaves has previously been investigated to have antibacterial activity against Propionibacterium acnes. An active compound propionibacterium acnes was flavonoid. Objective: This study aimed compare antimicrobial differences between nanoparticles and alone. Method: AC were extracted then formulated into using chitosan as the polymer s...