Running title: 3xTg-AD mouse cerebellum protected by scFv-h3D6 1 These authors made equally important contributions to this study. A u t h o r ' s d r a f t v e r s i o n Draft version of: Esquerda-Canals, Gisela, et al. " Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment " in MAbs (ed. Abstract The therapeutic potential of scFv-h3D...

Replication-deficient recombinant adenovirus (Ad) encoding human gp100 or MART-1 melanoma Ag was used to transduce human dendritic cells (DC) ex vivo as a model system for cancer vaccine therapy. A second generation E1/E4 region deleted Ad which harbors the CMV immediate-early promoter/enhancer and a unique E4-ORF6/pIX chimeric gene was employed as the backbone vector. We demonstrate that human...

Alzheimer's disease (AD) is an incurable neurodegenerative disease and many types of stem cells have been used in AD therapy with some favorable effects. In this study, we investigated the potential therapeutical effects of human dental pulp stem cells (hDPSCs) on AD cellular model which established by okadaic acid (OA)-induced damage to human neuroblastoma cell line, SH-SY5Y, in vitro for 24 h...

Previous findings indicate that the acquisition and consolidation of recognition memory involves dopaminergic activity. Although dopamine deregulation has been observed in Alzheimer's disease (AD) patients, the dysfunction of this neurotransmitter has not been investigated in animal models of AD. The aim of this study was to assess, by in vivo microdialysis, cortical and hippocampal dopamine, n...

An interesting and recently much studied generalization of the classical Schur class is the class of contractive operator-valued multipliers S(λ) for the reproducing kernel Hilbert space H(kd) on the unit ball B d ⊂ C, where kd is the positive kernel kd(λ,ζ) = 1/(1 − 〈λ, ζ〉) on B . The reproducing kernel space H(KS) associated with the positive kernel KS(λ,ζ) = (I −S(λ)S(ζ)∗) · kd(λ,ζ) is a nat...

H amlet is reading a magazine. His eye is caught by an advertisement for the Great Dane sword. The ad pictures Fortinbras ra is i~~g the sword in battle. The ad proclaims, "10 Reasons Why the Great Dane Outperforms Its Competitors!" The ad continues, "Reason #I: Because of its sharper blade, the Great Dane kills fa~ter and more decisively." Hamlet, who had never heard of the Great Dane before, ...