Originally the syndrome was described in South Africa at 1920, but at present it is endemic in Jamaica, encountered in Afghanistan and India. The syndrome was described under dif‐ ferent names, from Jamaica the disease was described under the term Jamaican veno-occlu‐ sive disease, in India the disease was given the term Indian childhood Cirrhosis (ICC), in Europe HVOD has been called endophleb...

Hepatitis B virus (HBV) infection is a global human health problem, with an estimated 350 million people having chronic hepatitis B (CHB) infection worldwide. The majority of infections acquired during adulthood are resolved without intervention; however, infections acquired at birth or during early childhood have a 90% chance of progressing to CHB, leading to a host of adverse effects on the l...

Walker-Smith, J. A., and Blomfield, J. (1973). Archives of Disease in Childhood, 48, 476. Wilson's disease or chronic copper poisoning? The case history is given of a child who presented at 14 months with ascites and was found to have severe micronodular cirrhosis with biochemical evidence of Wilson's disease, but in view of the severity of the pathology and early age of presentation, the possi...

Liver cirrhosis is a disease characterized by the loss of functional liver mass. Physiologically based pharmacokinetic (PBPK) modeling was applied to interpret and predict how the interplay among physiological changes in cirrhosis affects pharmacokinetics. However, previous PBPK models under cirrhotic conditions were developed for permeable cytochrome P450 substrates and do not directly apply t...

Aim Despite advances in the management of liver diseases and changes etiology cirrhosis, few studies have updated prognosis cirrhosis. This study aimed to clarify recent cirrhosis identify risk factors for death. Methods In this retrospective observational by Hepatic Disease Network National Hospital Organization Japan, chart reviews were performed follow patients with beginning 2011. We conduc...

The small subunit (SSU) processome is a large ribonucleoprotein that is required for maturation of the 18S rRNA of the ribosome. Recently, a missense mutation in the C-terminus of an SSU processome protein, Utp4/Cirhin, was reported to cause North American Indian childhood cirrhosis (NAIC). In this study, we use Saccharomyces cerevisiae as a model to investigate the role of the NAIC mutation in...

none of the approved immunomodulatory drugs in adults multiple sclerosis (ms) patients have been officially approved for the pediatric patients and are currently used off-label in this population. in this study, we evaluated the effectiveness and tolerability of intramuscular interferon beta1-a (avonex®) and subcutaneously injected interferon beta1-b (betaferon®) in children with definite relap...

inguinal mass is a common clinical finding or even symptom in childhood while the most common diagnosis is inguinal hernia that may proceed with prompt surgical but there are a vast variety of different entities that may manifest as an inguinal mass and in some instances, surgical approach is not indicated or may need further preoperative assessments to determine a correct therapeutic plan. in ...

methods in this study, 150 children diagnosed with liver disease and ascites upon admission to nemazee teaching hospital (shiraz, iran) were examined. patients were divided into spontaneous bacterial peritonitis and sterile ascetic fluid groups according to the pmn count ≥ 250/mm3 in the ascetic fluids. routine laboratory tests were conducted and quantitative c-reactive protein (crp) levels wer...