Purpose: Shorter constitutional telomere length has been associated with increased cancer incidence. Furthermore, telomere shortening is observed in response to intensive chemotherapy and/or ionizing radiation exposure. We aimed to determine whether less telomere content was associated with treatmentrelated second malignant neoplasms (SMN) in childhood cancer survivors. Experimental Design: Usi...

Abstract Background Data on childhood and adolescent malignant tumors incidence are skimp in developing countries. In this study, we analyzed the incidence and trend of childhood and adolescent cancers in Yazd city, center of Iran between Jan 2004 and Dec 2013. Materials and Methods The various types of malignant tumors were grouped pursuant to the Interna...

Male patients with childhood, adolescent, and young adult cancer are at an increased risk for infertility if their treatment adversely affects reproductive organ function. Future fertility is a primary concern of families. Variations in clinical practice barriers to the timely implementation interventions that preserve fertility. As part PanCareLIFE Consortium, collaboration International Late ...

Measurement of incidence rates of childhood cancer in Africa is difficult. The study 'Cancer of Childhood in sub Saharan Africa' [Stefan C, Bray F, Ferlay J, Parkin DM and Liu B (2017) Cancer of Childhood in sub-Saharan Africaecancer11(755)] brings together results from 16 population-based registries which, as members of the African Cancer Registry Network (AFCRN), have been evaluated as achiev...

PURPOSE Although most children with cancer live in low- and middle-income countries, measurements of childhood cancer burden in such countries have been restricted to incidence rates from a few subnational cancer registries and mortality rates from vital statistics. We aimed to provide alternative burden estimates by using nationally representative longitudinal survey-derived mortality rates. ...

this article reviews the recently published data on the diagnosis of cancer with proteomics, including the major proteomics technologies and promising strategies for biomarker discovery and development.  most of the tumor markers are proteins that either numerically increase in response to the alteration of cancer conditions or are produced by cancer cells. however, they are natural compounds o...

TO THE EDITOR: It goes without saying that Levinson and Lurie’s Perspective, “When Most Doctors Are Women: What Lies Ahead?” (1), has created a great deal of interest and, particularly with physicians who are women, a great deal of discussion. My choice of words in the previous sentence, however, really highlights the problem— these women are physicians. We should not attach the label “women ph...

OBJECTIVES To investigate whether childhood cancer is associated with intramuscular administration of vitamin K to newborn infants. DESIGN Routines for administration of vitamin K to infants born after normal deliveries during 1973-89 were obtained from maternity hospitals. Occurrence of cancer up to the end of 1991 was identified by comparing these records with the national cancer registry. ...

PURPOSE Shorter constitutional telomere length has been associated with increased cancer incidence. Furthermore, telomere shortening is observed in response to intensive chemotherapy and/or ionizing radiation exposure. We aimed to determine whether less telomere content was associated with treatment-related second malignant neoplasms (SMN) in childhood cancer survivors. EXPERIMENTAL DESIGN Us...

Brain tumors are the second most common cancer in children after leukemia and constitute about 20% of all childhood cancers in the United States (1). The annual incidence is approximately 34 pen million children under 15 years of age. The incidence may be rising; the U.S. National Cancer Institute reported an increase in the period 1973-1988 (1). With a 5-year relative survival rate of approxim...