aim and background: hepatocellular carcinoma (hcc) -an aggressive malignancy with high rate of mortality- is the third cause of cancer related death, worldwide. cisplatin is a chemotherapy drug used for treatment of hcc. however, serious side effects of drug limit the therapeutic administer dose.  nanotechnology based devices such as liposome nanoparticles are capable to overcome these drawback...

A brief review of the "state of the art" (1992) knowledge concerning various strategies and tactics to overcome multidrug resistance is presented. Multidrug resistance remains the main obstacle to long-term successful cancer chemotherapy; its prevention or elimination is probably one of the most promising avenues in cancer research.

Background: Peritoneal metastases (PM) are a common manifestation of gastro-intestinal and gynecological cancers. Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) has been proposed as new drug delivery technique to treat patients with PM. During this procedure, CO2 pneumoperitoneum (12 mmHg) is established. Subsequently, nebulizer (Capnopen®, Zimmern, Germany) aerosolizes the chemothera...

Nausea and vomiting are major concerns for patients who have to receive chemotherapy for an underlying malignancy. In this review, these concerns faced by patients receiving chemotherapy are presented along with discussion of the mechanisms of chemotherapy induced nausea and vomiting. Major targets of the 5HT3 antagonists, the NK1 antagonists and the dopamine antagonists are discussed along wit...

Head and Neck Cancer (HNC) is a broad category of cancer, comprises cancer that origin into oral cavity, pharynx, larynx, sinuses salivary gland. Majority cases reported in Pakistan are metastatic to with morphology squamous cell carcinoma. Locally advance, un-resectable tumors treated systemic therapies. Commonly prescribe therapies includes chemotherapy targeted therapy. However, the most pre...

abstract background: chemotherapy- induced nausea and vomiting (cinv) occur frequently causing problems with an unacceptably high incidence that significantly affect patients' daily functioning and health-related quality of life. the present study was aimed to compare acute cinv for granisetron as 5-ht3 receptor antagonist and metoclopramide in the patients receiving chemotherapeutic regimens i...

Although intratumoral chemotherapy administration has been evaluated in the past, its results have not been frequently comparable to those from systemic administration. We recently described microdialysis as a method for local chemotherapy administration with increasing effectiveness while reducing systemic toxicity. We present a mathematical model which supports the successful application of t...

molecularly targeted anticancer therapy with conventional cytotoxic chemotherapy. Such combinations can come about only through rational design of clinical trials, taking into account the pharmacology and clinical development of the drugs involved. It is therefore worthwhile revisiting classical chemotherapy agents, because this renewed knowledge could provide a foundation for future trials. Ox...