Hodgkin lymphoma (HL) is a leading cause of cancer among adolescents, and is often cured with chemotherapy alone or in combination with radiation therapy. Awareness of potential adverse cardiovascular sequelae due to therapy is crucial. Radiation-induced heart disease can affect cardiovascular structures in the radiation field, and risks of cardiovascular damage can be further increased due to ...

Premature ovarian failure may be a consequence of gonadotoxic cytotoxic chemotherapy or radiation therapy for malignant or systemic disease often resulting in major quality of life concerns. This is the first reported case in the English-speaking Caribbean using in-vitro fertilization (IVF) donor egg sharing in a patient who experienced premature ovarian failure following chemotherapy and radia...

Long-term endocrine disorders are the most frequent complications in survivors of adult and paediatric nasopharyngeal carcinoma (NPC). The hypothalamic-pituitary (h-p) axis lies within the field of radiation therapy for NPC. Consequently, neuro-endocrine abnormalities due to radiation-induced damage of the h-p occur in the majority of patients followed long term. Similarly, radiation injury to ...

BACKGROUND To evaluate acute toxicity endpoints in a cohort of patients receiving head and neck radiation with proton therapy or intensity modulated radiation therapy (IMRT). METHODS Forty patients received comprehensive head and neck radiation including bilateral cervical nodal radiation, given with or without chemotherapy, for tumors of the nasopharynx, nasal cavity or paranasal sinuses, an...

Abstract BACKGROUND Studies investigating dose-dependent effects of cranial irradiation (CRT) in children with posterior fossa brain tumors are limited by examining combined surgery, chemotherapy, and radiation. We aimed to determine alterations volume microstructure, neuropsychological outcomes treated surgery alone, CRT combined. explored the relationship radiation dose thalamus, putamen, hip...

Background: Low-grade astrocytomas are the most common pediatric central nervous system tumours. They can occur anywhere in the central nervous system and are often challenging to treat. Methods: A retrospective review to compare the response to therapy for spinal cord astrocytomas to that of brain astrocytomas. Results: Five patients had low-grade spinal cord astrocytoma and 43 had low-grade b...

Background: The fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.The high linear energy transfer (LET) of alpha radiation to the targeted cancer cellscauses double strand breaks in DNA. At the same time, the short range radiation spares adjacent normal tissues. This targeted approach complements conventional external beam radiotherapy and ch...

abstract objective the great majority of patients with childhood leukemia become long-term survivors. they treated with chemotherapy and prophylactic central nervous system (cns) irradiation. the aim of this cross-sectional study was to evaluate effect of the long-term toxicity in all survivors, and possible effects of this treatment on their intellectual in compare with their sibling. material...

BACKGROUND Hyperthermia has long been used in combination with chemotherapy or radiation therapy for the treatment of superficial malignancies, in part due to its sensitizing capabilities. Patients who suffer from superficial recurrences of breast cancer have poor clinical outcomes. Skin metastases may particularly impair the quality of life due to the physical appearance, odor and bleeding. ...