Lead is known to be a potent neurotoxin that can cause seizure activity in humans and animals. Also, epileptic type convulsion is a known complication of hypothyroidism. This study was performed to determine the effect of propylthiouracil (PTU)-induced hypothyroidism and chronic lead exposure on pentylenetetrazol (PTZ)-induced kindling parameters. The test was carried out by using male alb...

objective(s): stress induces many homeostatic aberrations which are followed by lifelong allostatic responses. epilepsy is developed or influenced by different environmental factors, i.e. prenatal stress which makes many contradictory developmental changes in seizure threshold and intensity. we investigated the potential seizure response of the rat offspring to prenatal stress; the stress which...

lead is known to be a potent neurotoxin that can cause seizure activity in humans and animals. also, epileptic type convulsion is a known complication of hypothyroidism. this study was performed to determine the effect of propylthiouracil (ptu)-induced hypothyroidism and chronic lead exposure on pentylenetetrazol (ptz)-induced kindling parameters. the test was carried out by using male albino r...

low frequency stimulation (lfs) is a potential alternative therapy for epilepsy. however, it seems that the anticonvulsant effects of lfs depend on its target sites in the brain. thus, the present study was designed to compare the anticonvulsant effects of lfs administered to amygdala, piriform cortex and substantia nigra on amygdala kindling acquisition. in control group, rats were kindled in ...

Introduction: The claustrum interconnects with the allocortical and neocortical regions and also projects to the hippocampus and the amygdala. .The role of claustrum in the complex partial seizure is not clear. Thus in this study the effect of amygdala lesion on anterior claustrum kindled seizures in rat were investigated. Methods: Male Wistar rats, weighting 250-300 g, were received DC curren...

Introduction: Although hippocampus is the most famous brain area involved in temporal lobe epilepsy, hippocampal kindling (HK) develops very slowly. Hence, rapid kindling is usually preferred to the traditional kindling and it is widely used. In this article we aimed at finding the optimal stimulus pattern, which yields the fastest HK rate. Methods: Stimulus patterns with different duratio...

BACKGROUND In humans, convulsive diseases such as temporal lobe epilepsy are usually accompanied by learning and memory impairments. In recent years, the role of gap junction channels as an important target of antiepileptic drugs has been studied and discussed. Quinine, as a gap junction blocker of connexin 36, can abolish ictal epileptiform activity in brain slices. OBJECTIVES The role of qu...

Traumatic Brain Injury (TBI) is one of the leading causes of death and disability in the population worldwide, with a broad spectrum of symptoms and disabilities. Post-traumatic hyperexcitability is one of the most common neurological disorders that affect people after a head injury. A reliable animal model of post-traumatic hyperexcitability induced by TBI which allows one to test effective tr...

Modern computational approaches based on quantum mechanical methods to characterize structures and optical spectra of biological chromophores in the gas phase, in solutions and proteins are discussed. Primary attention is paid to the chromophores from the family of the green fluorescent protein (GFP) widely used as a biomarker in living cells. Beyond GFP, photophysical properties of the monomer...

PURPOSE The ketogenic diet (KD) has been used as an effective antiepileptic treatment for nearly a century. Inhibition of glycolysis and increased levels of ketone bodies are both known to contribute to the antiepileptic effects of the KD. Neuron-restrictive silencer factor (NRSF), also known as RE-1 silencing transcription factor (REST), is implicated in the antiepileptic effects of the glycol...