HIV-1 integrase is an essential enzyme for the replication cycle, and currently, inhibitors are in first line of treatment many guidelines. Despite discovery new inhibitors, including a class molecules with different mechanisms action, resistance still relevant problem, adding options to therapeutic arsenal fight viral Sisyphean task. Because difficulty cost vitro screenings, machine learning-d...

Thymidylate synthase (TS) is a well-validated target for cancer chemotherapy. TS was established as the principal target of the widely used anticancer drug 5-fluorouracil (5FU). The 5FU metabolite FdUMP forms a covalent complex with TS that is stabilized by 5-formyl tetrahydrofolate (leucovorin; LV). Numerous chemical strategies have been employed to develop novel TS inhibitors that are superio...

The influence of hydrogen phosphate (HPO42−) and molybdate ions (MoO42−) on the behavior tin corrosion in 0.2 M maleic acid was compared using experimental theoretical techniques. studies consisted electrochemical investigations (potentiodynamic polarization (PDP) impedance spectroscopy (EIS)), along with surface analytical techniques (SEM EDX). Additionally, analysis (the chemical quantum comp...

We wondered if depression of oxidative adenosine triphosphate (ATP) production caused pulmonary vasoconstriction. If so, then several chemically different inhibitors of oxidative ATP production all should cause pulmonary pressor responses. The vascular reactivity of isolated, blood-perfused rat lungs was established by eliciting pressor responses to airway hypoxia and to intraarterial angiotens...

Horsegram (Dolichos biflorus), a protein-rich leguminous pulse, is a crop native to Southeast Asia and tropical Africa. The seeds contain multiple forms of Bowman-Birk type inhibitors. The major inhibitor HGI-III, from the native seed with 76 amino acid residues exists as a dimer. The amino acid sequence of three isoforms of Bowman-Birk inhibitor from germinated horsegram, designated as HGGI-I,...