Server consolidation is a vital mechanism in modern data centers in order to minimize expenses with infrastructure. In most cases, server consolidation may require migrating virtual machines between different physical servers. Although the downtime of live-migration is negligible, the amount of time to migrate all virtual machines can be substantial, delaying the completion of the consolidation...

Acquiring a new skill requires learning multiple aspects of a task simultaneously. For example, learning a piano sonata requires learning the musical notes and being able to implement this goal by learning the appropriate sequence of finger movements. After practice, skill continues to develop off-line during a period of consolidation. Here we show that different aspects of a procedural memory ...

Residents of the Hudson-Mohawk River Watershed and the state of New York face serious challenges during coming years to maintain water infrastructure, including both water supply and sewage treatment. For example, maintaining wastewater infrastructure is expected to cost more than $36 billion by 2028 (NY-DEC 2008). Given this extremely high cost, one of the few potential opportunities for subst...

Hungry fruit flies can be trained by exposing them to two chemical odorants, one paired with the opportunity to feed on 1 M sucrose. On later testing, when given a choice between odorants the flies migrate specifically toward the sucrose-paired odor. This appetitively reinforced learning by the flies is similar in strength and character to previously demonstrated negatively reinforced learning,...

Frataxin (FXN) is an α/β protein that plays an essential role in iron homeostasis. Apparently, the function of human FXN (hFXN) depends on the cooperative formation of crucial interactions between helix α1, helix α2, and the C-terminal region (CTR) of the protein. In this work we quantitatively explore these relationships using a purified recombinant fragment hFXN90-195. This variant shows the ...

The past four decades has witnessed a consolidation of the original observations made in the 1970s that dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) have an immunological basis. Following reinfection with a dengue virus of different serotype, severe disease is linked to high levels of antibody-enhanced viral replication early in illness which is followed by a cascade of memor...

10 to 15% of acute myeloid leukemia cases are patients with acute promyelocytic leukemia (APL). There are unique features of APL as reciprocal translocation between the long arms of chromosomes 15 and 17, younger age of onset, and severe consumptive coagulopathy with a high incidence of early fatal hemorrhage. Current treatment of APL combines alltrans-retinoic acid (ATRA) with anthracyclinebas...

Our recent data have indicated that scopolamine, a non-selective muscarinic receptor antagonist, improves memory consolidation, in a passive avoidance task, tested in rats. It has been found that verapamil, a phenylalkylamine class of the L-type voltage-dependent calcium channel antagonist, inhibits [3H] N-methyl scopolamine binding to M1 muscarinic receptors. However, there are no data about t...

Learning is considered to consist of two distinct phases-acquisition and consolidation. Acquisition can be disrupted when short periods of training on more than one task are interleaved, whereas consolidation can be disrupted when a second task is trained after the first has been initiated. Here we investigated the conditions governing the disruption to acquisition and consolidation during mixe...

The hippocampus is critical for the storage of new autobiographical experiences as memories. Following an initial encoding stage in the hippocampus, memories undergo a process of systems-level consolidation, which leads to greater stability through time and an increased reliance on neocortical areas for retrieval. The extent to which the retrieval of these consolidated memories still requires t...