BACKGROUND AND OBJECTIVE The hamster cheek pouch carcinogenesis model, using chronic treatments of dimethylbenz[alpha]anthracene (DMBA) was used as a model system to investigate changes in epithelial tissue autofluorescence throughout the dysplasia-carcinoma sequence. STUDY DESIGN/MATERIALS AND METHODS Fluorescence emission spectra were measured weekly from 42 DMBA-treated animals and 20 cont...

Aortic Endothelial Cell Replication. I. Effects of Age and Hypertension in the Rat. Stephen M. Schwartz and Earl P. Benditt 248 The Effect of Norepinephrine on Aortic K Turnover during Deoxycorticosterone Acetate Hypertension and Antihypertensive Therapy in the Rat. Allan W. Jones, Paul D. Sander, and Donald L. Kampschmidt 256 The Cig-Mineralocorticoids in Hypertension. Jordan A. Sennett, Larry...

Optical imaging techniques using a variety of contrast mechanisms are under evaluation for early detection of epithelial precancer; however, tradeoffs in field of view (FOV) and resolution may limit their application. Therefore, we present a multiscale multimodal optical imaging system combining macroscopic biochemical imaging of fluorescence lifetime imaging (FLIM) with subcellular morphologic...

We compared the shortening velocity of smooth muscle in arterioles that had low or high levels of myogenic tone or norepinephrine (NE)-induced tone. We hypothesized that enhanced myogenic tone of arterioles reflects an enhanced maximum velocity of shortening of arteriolar smooth muscle in a way that is different from that produced by NE. These concepts are untested assumptions of arteriolar mec...

and clinical tumors is under study in many laboratories and is leading to the accumulation of a sizable catalogue of tumor cell parameters (1—6,8, 10—16,18, 20—24). On the basis of such measurements, there is as yet little to dis tinguish the tumor cell from a variety of normal cells which have also been analyzed. Since the tumor cell and normal cell have usually been measured independent...

The effect of hyaluronidase on host connective tissue and the protective action of the hyaluronic acid capsule against phagocytosis have been the basis for a number of studies on the relation of these products to the virulence of streptococci. Duran-Reynals (1933) demonstrated that the areas of dermal lesions produced by several strains of streptococci were largely a function of the amount of h...

OBJECTIVE To observe the effect of Erigeron breviscapus (Vant) Hand Mazz (HEr) in impeding oral leukoplakia carcinogenesis, and to seek effective Chinese herb medicine that can impede precarcinoma of oral mucosas. METHODS 132 golden hamsters were randomly divided into model group (60 animals), HEr group (60 animals), and control group 12 animals. Salley's leukoplakia carcinogenesis model of g...

Optical measurements of metabolism are ideally acquired in vivo; however, intravital measurements are often impractical. Accurate ex vivo assessments would greatly broaden the applicability of optical measurements of metabolism. We investigate the use of live tissue culture experiments to serve as a surrogate for in vivo metabolic measurements. To validate this approach, NADH and FAD fluorescen...

Desmosomes in stratified squamous epithelia appear to exhibit quantitative alterations during differentiation. In this work we use stereological and other morphometric methods to quantify these structures in epithelial cells from defined basal, spinous and granular strata. Hamster cheek pouch mucosa from five animals was processed for electron microscopy using strictly standardized techniques a...