The Chediak-Higashi syndrome (CHS) has been reported in man, cattle, mink, and mice. CHS humans and cattle have an increased incidence of pyogenic infections, whereas CHS mink are more susceptible to Aleutian disease. Age- and sex-matched groups of CHS mice (mutant strain) and C57 Bl/6N (parent strain) were challenged with Candida albicans, Escherichia coli, Klebsiella pneumoniae, and Staphyloc...

Granulocyte function was evaluated using activity of S. aureus and group D strepperitoneal exudate granulocytes from a tococcus by CHS cells through 90 mm of instrain of beige mice with the Chediak-Hicubation. The bactericidal defect was most gashi syndrome (CHS). Defective granupronounced at early time periods and was locyte chemotaxi of CHS cells (43% related to impaired intracellular killing...

By P. EFRATI AND W. JONAS CHEDIAK, in 1952, published the first case of an anomaly of leukocytes, which was named after him. The patient was a young boy who died two years after the examination. In addition to the bctikocytc anomaly he exhibited hepatosp!enomegaly, lymphadenopathy, anemia, thrombocytopenia and neutropenia. The boy and his three brothers were albinos with marked photophobia. The...