Adult goats (no. = 18) were supplemented with chromium (Cr, 0.5 mg/kg concentrate) for 120 days as Cr chloride and Cr yeast complex and their responses in terms of glucose tolerance and serum profiles of metabolites and hormones were measured. The goats were fed 200 g/day of the concentrate and reared under a semi-intensive regimen. Cr supplementation significantly reduced serum glucose ( P = 0...

This study compared two methods for identifying troublesome examination questions: a postexam student "challenge committee" process and a "question citation" procedure allowing students to identify troublesome questions during an exam. Challenged and cited questions on eight examinations given to second-year medical students were compared with respect to the percentage of correct responses (%CR...

Both current and historical patterns of variation are relevant to understanding and managing ecological diversity. Recently derived species present a challenge to the reconstruction of historical patterns because neutral molecular data for these taxa are more likely to exhibit effects of recent and ongoing demographic processes. We studied geographical patterns of neutral molecular variation in...

PURPOSE Given that the prognosis of recurrent malignant glioma (MG) remains poor, improving quality of life (QoL) through symptom management is important. Meta-analyses establishing antiemetic guidelines have demonstrated the superiority of palonosetron (PAL) over older 5-hydroxytryptamine 3-receptor antagonists in chemotherapy-induced nausea and vomiting (CINV) prevention, but excluded patient...

Crossbred steers (n = 20; 235 ± 4 kg) were fed for 53 d during a receiving period to determine if supplementing chromium (Cr; KemTRACE Chromium Propionate 0.04%, Kemin Industries, Des Moines, IA) would alter glucose or lipid metabolism of newly received cattle. Chromium premixes were supplemented to add 0 (Con) or 0.2 mg/kg of Cr to the total diet on a DM basis. Cattle were fitted with jugular ...

A poor prenatal environment brings about perturbations in leptin surge and hypothalamic circuitry that program impaired ability to regulate energy homeostasis in adulthood. Here, using a rat model of moderate maternal caloric restriction during gestation, we aimed to investigate whether leptin supplementation with physiological doses throughout lactation is able to ameliorate the adverse develo...

BACKGROUND Patterns of therapy switching in patients receiving long-acting opioids have not been well documented. OBJECTIVE To compare therapy switching among patients beginning treatment with controlled-release (CR) oxycodone, transdermal fentanyl, or CR morphine sulfate. METHODS Using a US healthcare claims database, we identified patients beginning treatment with CR oxycodone, transderma...

RATIONALE Caloric restriction (CR) confers cardioprotection against ischemia/reperfusion injury. However, the exact mechanism(s) underlying CR-induced cardioprotection remain(s) unknown. Recent evidence indicates that Sirtuins, NAD(+)-dependent deacetylases, regulate various favorable aspects of the CR response. Thus, we hypothesized that deacetylation of specific mitochondrial proteins during ...

The aim of the present study was to examine and understand changes in platelet functions prior to and after the treatment of primary immune thrombocytopenia (ITP) in children. An automatic hematology analyzer and whole blood flow cytometry were used to detect immature platelet fraction (IPF), IPC and membrane glycoproteins (CD62p, PAC-1 and CD42b) in ITP children (ITP group), children with comp...

In this paper we report a search for intermediate mass magnetic monopoles and nuclearites using CR39 and Makrofol Nuclear Track Detectors (NTDs) of the SLIM large area experiment, 440 m exposed at the high altitude laboratory of Chacaltaya (Bolivia) and about 100 m at Koksil, Himalaya (Pakistan). We discuss the new chemical etching and improved analysis of the SLIM CR39 sheets. Preliminary limi...