BACKGROUND Abnormal Savda Munziq (ASMq), a traditional uyghur medicine, has shown anti-tumour properties in vitro. it was showed that total flavonoids of ASMq could inhibit the proliferation and enhance the antioxidant ability of human cervix cancer HeLa cell. This study attempts to confirm these effects on the transplanted cervical cancer (U27) mouse model in vivo. METHODS Forty eight Kunmin...

conclusions trachelectomy represents a valuable conservative surgical approach for stage invasive cervical cancer. case report a 30-years-old woman with squamous cell cervical cancer stage (1 a ii) diagnosed at september 2011 expressed a wish for fertility-sparing treatment. radical abdominal hysterectomy and pelvic and para-aortic lymphadenectomy were performed which showed no evidence of lymp...

BACKGROUND Tissue factor pathway inhibitor-2 (TFPI-2) is an extracellular matrix associated broad-spectrum Kunitz-type serine proteinase inhibitor. Recently, down regulation of TFPI-2 was suggested to be involved in tumor invasion and metastasis in some cancers. METHODS This study involved 12 normal cervical squamous epithelia, 48 cervical intraepithelial neoplasia (CIN), and 68 cervical canc...

Mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 3 (MEKK3) is an important protein kinase and a member of the MAPK family, which regulates cellular responses to environmental stress and serves as key integration points along the signal transduction cascade that not only link diverse extracellular stimuli to subsequent signaling molecules but also amplify the ...

Background: Cervical cancer is one of the main reasons death in developing countries around world, with an incidence sixty-one percent females, so it important to detect precancerous lesion decrease morbidity and mortality rates due cervical cancer.

In cervical cancer, glycosylation has been suggested as being involved in both its carcinogenesis and invasive capacity. In this work, we analyzed mucin type O-glycosylation in biopsies of invasive cervical cancer in FIGO stage II B through histochemistry using lectins specific for O-glycosidically linked glycans. Our results reveal that the lectin Machaerocereus eruca (MeA, specific for Gal in...

p53-binding protein 1 (53BP1) plays a key role in DNA damage response mechanism, which protects genome integrity and guards against cancer. Although abnormal DNA damage response type of 53BP1 nuclear foci (NF) have been indicated to be associated with many types of malignancies, how the staining pattern of 53BP1 NF and the mRNA level of 53BP1 correlate with the clinicopathologic characteristics...

OBJECTIVE This study was designed to investigate the expression and significance of the Forkhead Box M1 (FOXM1) transcription factor in human cervical cancer. METHODS The expression of FOXM1 protein was assessed in tissue microarrays containing 102 cervical cancer tissues by the Streptavidin-Peroxidase (SP) immunohistochemistry technique. The relationship between FOXM1 protein and clinico-pat...

OBJECTIVE IL-17A plays an important role in many inflammatory diseases and cancers. We aimed to examine the effect of IL-17A on the invasion of cervical cancer cells and study its related mechanisms. METHODS Wound healing and matrigel transwell assays were used to examine the effect of IL-17A on cervical cancer cell migration and invasion by a panel of cervical cancer cell lines. The levels o...

The screening of cancer is important in secondary prevention in clinical oncology. The cervical cancer screening by pelvic examination and Pap smear test is the standard practice worldwide. However, the coverage of the screening is an important consideration in public health. Some specific vulnerable populations are considered to have a low chance of having access to health care services includ...