Cerebrospinal fluid (CSF) immunoglobulins (IgA, IgG, IgM) were measured in 107 patients with meningococcal meningitis. Levels were correlated significantly with CSF total protein, and both CSF immunoglobulin and protein increased with age. C3 was measured in the CSF of 38 patients and was also closely correlated with the CSF protein level. C3 breakdown products were found in all six CSFs tested...

Until recently it has been generally accepted that the choroid plexuses are the major source of the cerebrospinal fluid (CSF). However, data now indicate that significant contributions to the CSF are made at extrachoroidal sites. CSF production studies and 24Na transport studies in normal and plexectomized rhesus monkeys supportive of substantial extrachoroidal CSF formation will be presented. ...

Probenecid may elevate the cerebrospinal fluid (CSF) concentration of penicillin G by inhibiting the excretion of organic acids from CSF. We have studied this phenomenon with various penicillin and cephalosporin derivatives. Penicillin concentrations were determined in rabbits under steady-state conditions before and after intravenous probenecid administration. With both low-dose and high-dose ...

oligoclonal bands (ocb) can be detected in a significant percentage (90%) of patients with multiple sclerosis (ms), however, a much lower percentage has been reported in some studies, mainly from oriental countries. on the other hand, ocb have been detected in other neurological disorders (ond), even in diseases without any definite evidence for inflammation in csf such as myasthenia gravis. th...

Case 3 is a rare congenital abnormality of the inner ear which usually presents as recurrent meningitis. This abnormality is now well documented.4 It should be suspected as a cause of recurrent meningitis in a child who has a sensorineural deafness. The presence of fluid behind the tympanic membrane should make one suspicious and the diagnosis can be confirmed by tomograms of the inner ear. The...

conclusions: even, very low amount of csf-igg with good specificity (90%); could differentiate cases and controls (p = 0.000). the csf-igg test (sensitivity 70%, npv 28.8%) was weak for ruling out the m. pneumonia in cases. positive pcr was rare (2%) in csf of cases and controls but is more reliable for diagnosing the recent m. pneumonia infection. we prefer to assay the csf for both serology a...

The effects of hydration status on cerebral blood flow (CBF) and development of cerebrospinal fluid (CSF) lactic acidosis were evaluated in rabbits with experimental pneumococcal meningitis. As loss of cerebrovascular autoregulation has been previously demonstrated in this model, we reasoned that compromise of intravascular volume might severely affect cerebral perfusion. Furthermore, as acute ...

FENCL, V., T. B. MILLER, AND J. R. PAPPENHEIMER. Studies on the respiratory response to distwbances of acid-base balance, with deductions concerning the ionic cornposition of cerebral interstitial @id. Am. J. Physiol. 2 I o(3) : 459-472, I g66.-Respiratory responses to inhaled (202 were studied on five unanesthetized goats during chronic metabolic acidosis or alkalosis. Measurements were made o...

Adiponectin circulates in the body in high concentrations, and 100-fold lower amounts were described in the cerebrospinal fluid (CSF) of mice, whereas in humans, contradictory results have been published. To clarify whether adiponectin is present in human CSF and is derived from the circulation, it was determined in human CSF and plasma of 52 nonselected patients. Adiponectin was detected by im...

Background: Auto-antibodies against granulocyte-macrophage colony stimulating factor (GM-CSF) may be central to the pathogenesis of adult sporadic pulmonary alveolar proteinosis (PAP). The role of antiGM-CSF auto-antibodies in paediatric forms of PAP is as yet unclear. Methods: Anti-GM-CSF auto-antibodies were determined with the help of an antigen capture assay using serum and/or bronchoalveol...