Meningioma presenting as ischemic stroke is very rare. We report a case of left medial sphenoid wing meningioma with cerebral infarction due to occlusion middle artery (MCA) in 36-year-old female. discuss the incidence, pathophysiology, management and review literature intracranial stroke.

Ischemic stroke is one of the leading causes of morbidity and mortality. Treatment options are limited and only a minority of patients receive acute interventions. Understanding the mechanisms that mediate neuronal injury and death may identify targets for neuroprotective treatments. Here we show that the aberrant activity of the protein kinase Cdk5 is a principal cause of neuronal death in rod...

BACKGROUND Histopathological analyses of debris captured by a cerebral protection system during transcatheter aortic valve replacement have been reported, but the origin of the captured debris was not determined and risk factors were not defined. METHODS AND RESULTS Embolic debris was analyzed from 322 filters used in a dual-cerebral-filter protection system implemented during transcatheter a...

PURPOSE To investigate the ability of map-ISODATA (Iterative Self-Organizing Data Analysis Technique) to classify the different categories of ischemic damage in the lesion and to evaluate a combined (thrombolysis plus antiplatelet) treatment efficacy in an embolic stroke of rat. MATERIALS AND METHODS Rats subjected to embolic stroke with (N=12) and without (N=10) rt-PA and 7E3 F(ab')2 treatme...

INTRODUCTION Diffusion-weighted (DW) MR imaging enables early identification of ischemic lesions in stroke. Stroke subtype may be related to different lesion patterns. The aim of this study was to analyze the subtype of ischemic lesions as determined by the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria by using DW MR imaging. METHODS AND RESULTS In this study, 510 consecutive ...

BACKGROUND AND PURPOSE Higher proportions of hemorrhagic stroke and lacunar infarction were reported in rural Japan compared with those in Western countries. We examined the relative proportions of stroke subtypes in an urban Japanese city where westernized lifestyles are more common than in rural areas. METHODS Stroke registration was performed in 1992, 1997, and 2002 for residents > or =40 ...

Embolic strokes of undetermined source comprise a subset of cryptogenic ischemic strokes. It is thought that some embolic strokes of undetermined source could be due to left atrial thromboembolism without atrial fibrillation. The authors sought to determine whether a marker of left atrial pathological changes could pose as a surrogate marker of nonarrhythmogenic atrial thromboembolism in emboli...

Embolic strokes of undetermined source comprise a subset of cryptogenic ischemic strokes. It is thought that some embolic strokes of undetermined source could be due to left atrial thromboembolism without atrial fibrillation. The authors sought to determine whether a marker of left atrial pathological changes could pose as a surrogate marker of nonarrhythmogenic atrial thromboembolism in emboli...

Tumor necrosis factor alpha (TNFalpha) is an immunomodulatory and proinflammatory cytokine implicated in neuroinflammation and neuronal damage in response to cerebral ischemia. Tumor necrosis factor-alpha converting enzyme (TACE or ADAM17) is a key sheddase that releases TNFalpha from its inactive cell-bound precursor. Using a selective small molecule inhibitor of TACE, DPH-067517, we tested th...