Early and accurate assessment of severity in acute pancreatitis (AP) is of great importance to provide effective disease management and prevent mortality. In this study, we aim to evaluate early indicators that predict the mortality of AP. We retrospectively analyzed 24-hour clinical characteristics and laboratory data in 166 AP patients recruited between January 2014 and November 2015 in Baoto...

In central neurons the first node of Ranvier is located at the first axonal branchpoint, ∼ 100 μm from the axon initial segment where synaptic inputs are integrated and converted into action potentials (APs). Whether the first node contributes to this signal transformation is not well understood. Here it was found that in neocortical layer 5 axons, the first branchpoint is required for intrinsi...

Certain consonant/vowel combinations (labial/central, coronal/front, velar/back) are more frequent in babbling as well as, to a lesser extent, in adult language, than chance would dictate. The "Frame then Content" (F/C) hypothesis (Davis & MacNeilage, 1994) attributes this pattern to biomechanical vocal-tract biases that change as infants mature. Articulatory Phonology (AP; Browman and Goldstei...

Direct visual observation is a common method for validation of animal behavior technologies; however, observations are time consuming and subject to human error. The objective this study was evaluate the RumiWatch system (Itin Hoch GmbH, Liestal, Switzerland), which composed noseband sensor pedometer, monitoring feeding locomotion behaviors grazing dairy cows, determine its accuracy use as benc...

Tsunami hazards along Chinese coast from potential earthquakes in South China Sea Yingchun Liu a,b,∗, Angela Santos d, Shuo M. Wang c, Yaolin Shi b, Hailing Liu a, David A. Yuen c a South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China b Graduate University of Chinese Academy of Sciences, Beijing, China c Department of Geology & Geophysics and Minnesota Supercom...

The mechanism and routes through which peptide tyrosine-tyrosine (PYY) exerts its anorectic effects are still largely unknown. In the present study, we investigated the roles of the area postrema (AP), subfornical organ (SFO) and vagus nerve in mediating the anorectic effect of PYY using PYY(3-36) conjugated to human serum albumin (PYY(3-36)-HSA) in rats. PYY(3-36)-HSA is a large molecule that ...

High-frequency action potential (AP) transmission is essential for rapid information processing in the central nervous system. Voltage-dependent Kv3 channels play an important role in this process thanks to their high activation threshold and fast closure kinetics, which reduce the neuron's refractory period. However, premature Kv3 channel closure leads to incomplete membrane repolarization, pr...

In central neurons, action potentials (APs) originate in the axon initial segment (AIS) presumably due to its high concentration of voltage-dependent sodium (NaV) channels. In the AIS, NaV and their cytoskeletal anchoring proteins display a highly periodical nanoscale arrangement with unknown functional relevance. In mouse hippocampal neurons, we examined a mutation of the AIS-specific protein ...