BACKGROUND Although autoimmune humoral abnormalities have been reported in patients with myelodysplastic syndromes (MDS), abnormal organ-specific cellular autoimmunity has not been demonstrated. METHODS Peripheral blood lymphocytes (PBLs) and serum were collected from a uveitis patient with MDS. Cellular immune response against retinal S-antigen (S-Ag) was assessed by proliferation assay, and...

complementary metal-oxide semiconductor (cmos) technology has been the industry standard to implement very large scale integrated (vlsi) devices for the last two decades. due to the consequences of miniaturization of such devices (i.e. increasing switching speeds, increasing complexity and decreasing power consumption), it is essential to replace them with a new technology. quantum-dot cellular...

context medication non-adherence is a commonly observed problem in the self-administration of treatment, regardless of the disease type. text messaging reminders, as electronic reminders, provide an opportunity to improve medication adherence. in this study, we aimed to provide evidence addressing the question of whether text message reminders were effective in improving patients’ adherence to ...

background: application of adjuvants with microbial origins is a recently highlighted approach in the vaccinology trials. archaeosomes are among these microbial compounds with both adjuvant and liposomal activities and features. methods: in the present study, recombinant hbsag encapsulated into methanobrevibacter smithii (m. smithii) archaeosomes. balb/c mice immunized with this compound and hu...

in the last decade, cellular automata models have been widely used for simulation spatial phenomena; however, exact nature of these models have been lead to various limitations for essential simulation of these phenomena. in this research, traditional cellular automata models have been developed through fuzzy theory, in which, transition rules are expressed based on fuzzy logic control methodol...

conclusions mobile phone text messaging increased adherence to diabetes therapy and improved the clinical outcome in saudi patients with type 2 diabetes. results in addition to significant improvement in patients’ knowledge, mean fasting blood glucose level improved from 8.60 ± 3.16 to 7.77 ± 3.11 mmol/l and mean hba1c decreased from 9.9% ± 1.8% to 9.5% ± 1.7%. objectives we conducted a study t...

sulfur mustard (sm, bis- (2-chloroethyl) sulphide) is a chemical warfare agent that causes dna alkylation, protein modification and membrane damage. sm can trigger several molecular pathways involved in inflammation and oxidative stress, which cause cell necrosis and apoptosis, and loss of cells integrity and function. epigenetic regulation of gene expression is a growing research topic and is ...

Objective(s): -methyl-D-aspartate NMDA receptor (NMDAR) and aquaporin 4 (AQP4) are involved in the molecular cascade of edema after traumatic brain injury (TBI) and are potential targets of studies in pharmacology and medicine. However, their association and interactions are still unknown.Materials and Methods: We established a rat TBI model in this study. The cellular distribution patterns of ...

PTEN (phosphatase with sequence homology to tensin) is a phosphatidylinositol 3,4,5-trisphosphate phosphatase that regulates many cellular processes. Activity of the enzyme is dependent on the redox state of the active site cysteine such that oxidation by H2O2 leads to inhibition. Because S-nitrosothiols are known to modify enzymes containing reactive cysteines, we hypothesized that S-nitrosoth...