Abstract Glycerol-based epoxy networks have great potential for surface functionalization, providing anti-microbial and protein repellant function. However, the synthesis of glycerol glycidyl ether (GGE) monomer often requires excessive epichlorohydrin (ECH). ECH derived organochloride containing byproducts from production maybe present in eluent polymer prepared by cationic ring-opening polyme...

Nanodiamonds (ND-COOH) are used as drug delivery systems because of their attractive properties, they allow for optimized transport therapeutic agents in cellular models. Metformin (MET) is a diabetes mellitus therapy and exhibits anti-cancer properties. In this study, dispersed nanodiamonds were functionalized with metformin by directly binding them to 1,6-hexanediol (ND-MET), effects on the c...

Abstract: A selected series of substituted sulphonamides were synthesized. These compounds were tested for potential antitumor activity against three of human tumor cell lines, Liver carcinoma cell line [HEPG2], Brain tumor cell line [U251] and Colon carcinoma cell line [HCT116]. Cytotoxic activity was assessed by SRB assay. The structures of the resulting compounds have been investigated by el...

There is no doubt that the contribution of microbially mediated bioprocesses toward maintenance of life on earth is vital. However, understanding these microbes in situ is currently a bottleneck, as most methods require culturing these microorganisms to suitable biomass levels so that their phenotype can be measured. The development of new culture-independent strategies such as stable isotope p...

In this paper, the structure of a new 16-membered macrocyclic Schiff base compound N,N′-(3,3′-dimethoxy-2,2′-(propane-1,3-diyldioxy)dibenzylidene)propane-1,3-diamine, C22H26N2O4 (1), derived from 1,3-propanediamine and 3,3′-dimethoxy-2,2′-(propane-1,3-diyldioxy)dibenzaldehyde has been studied by single crystal X-ray diffraction, DFT calculations at B3LYP/6-31G** and FT-IR spectroscopy. The titl...

Fourier-transform infrared (FT-IR) difference spectroscopy has been proven to be a significant tool in biospectroscopy. In particular, the step-scan technique monitors structural and electronic changes at time resolutions down to a few nanoseconds retaining the multiplex advantage of FT-IR. For the elucidation of the functional mechanisms of proteins, this technique is currently limited to repe...

EKB-569 (Pelitinib), an irreversible EGFR tyrosine kinase inhibitor has shown potential therapeutic efficiency in solid tumors. However, cell-killing potential in combination with radiotherapy and its underlying molecular orchestration remain to be explored. The objective of this study was to determine the effect of EKB-569 on ionizing radiation (IR)-associated NFκB-dependent cell death. SCC-4 ...

The aim of this study is to investigate ionic liquids (ILs) pretreatment on kempas composition, structure and enzymatic digestibility. Ground kempas (Koompassia malaccensis) was pretreated with 1-butyl-3-methylimidazolium acetate ([Bmim][OAc]), 1-butyl-3-methylimidazolium chloride ([Bmim]Cl) and 1-butyl-3-methylimidazolium trifluoromethansulfonate ([Bmim][OTf]), at 120°C for 6 and 12 h. The cel...