OBJECTIVE To establish whether honey and silver-impregnated dressings used by wound-healing practitioners are cytotoxic in vitro to human skin keratinocytes and dermal fibroblasts. METHOD Human keratinocyte and fibroblast tissue cultures were established in vitro. Untreated cultures served as controls (group I). Small dressing implants of monofloral, medicinal honey (L-Mesitran) (group 2) and...

Saraca indica is an important medicinal plant and the compounds present in this are very much helpful preventing various diseases. Therefore, aim of study was to investigate antioxidant activity vitro investigation S. extract on lead-induced toxicity HepG2 HEK293 cell lines. The assay performed by two methods such as 2,2-diphenyl-1-picrylhydrazyl (DPPH) 2,2′-azino-bis(3-ethylbenzothiazoline-6-s...

• Receptor and cell-based bioassays provided important insights into sediment toxicity. The included nine stress-activated receptors from fish. Chemical analyses of extracts revealed complex contamination profiles. Bioassays can be great importance for future environmental risk assessment. A luciferase reporter gene-based bioassay battery consisting fish, complemented with traditional fish bioa...

Background: Although various surface disinfectants have been introduced, most of them are toxic. The use of natural antimicrobial agent e.g. phytol, extracted from Leptadenia pyrotechnica is a new strategy. The aim of this study was to evaluate the antimicrobial activity, toxicity, and stability of phytol. Methods: The serial concentrations of phytol were prepared, and separately incubated with...

teucrium polium l. (tp) is widely used in traditional medicine of many countries including iran. there are various reports about pharmacological properties of tp such as calcium antagonist, anti- ulcer, anti – diabetic. there are a few reports about possible toxicological effects of this plant. in the present study we designed to evaluate the subchronic toxicity of teucrium polium total extract...

objective(s) ocimum basilicum l. is widely used in folk medicine of many countries including iran. both o. basilicum and its oil extract have received considerable attention for their potential medicinal properties, but there are a few reports about possible toxicity of this plant. therefore, in the present study, acute and subchronic toxicity of o. basilicum hydroalcohlic extract have been eva...

Objective(s): This study focused on determining cytotoxic effects of copper oxide nanoparticles (CuO NPs) on chronic myeloid leukemia (CML) K562 cell line in a cell-specific manner and its possible mechanism of cell death. We investigated the cytotoxicity of CuO NPs against K562 cell line (cancerous cell) and peripheral blood mononuclear cell (normal cell). Materials and Methods: The toxicity w...

the aberrant assembly of proteins into fibrillar aggregates is accused to be the primary cause of pathogenesis of neurodegenerative diseases. but the structural determinants of protein fibrils that are responsible for cell dysfunction are not yet clear. in the current study, cell culture, spectroscopic techniques as well as theoretical and structural investigations were used to determine the ab...

Glutamate kills neuronal cells by either a receptor-mediated pathway or the inhibition of cystine uptake, the "oxidative pathway." Antioxidants can block cell death initiated by either pathway, suggesting that toxicity is dependent on the production of free radicals. We provide evidence that in a neuronal cell line, glutamate toxicity via the oxidative pathway requires monoamine metabolism as a...