objective: cell vital function has correlation with mechanical loadings that cell experiences. here, effects of in-vitro combined cyclic-static stretch on proliferation of human mesenchymal stem cell (hmsc) were evaluated. materials and methods: hmscs were cultured on gelatin coated elastic membranes, and exposed to stretch loading. four different regimes of cyclic, static, combined cyclic-sta...

Thioridazine (TZ) is used mainly in the treatment of schizophrenia. However, hepatotoxicity as a life-threatening adverse effect is associated with its clinical use. In this context, we examined the cytotoxic mechanisms of TZ on freshly isolated rat hepatocytes to better understanding of the pathogenesis of TZ-induced hepatotoxicity. Hepatocytes were prepared by the method of collagenase enzyme...

Aquaporins are integral membrane proteins from a larger family of major intrinsic proteins that formpores in the membrane of biological cells. Aquaporins form tetramers in the cell membrane with eachmonomer acting as a water channel.In this research, the AQP4 tetramer was modeled from its PDBstructure file, then, we have performed the intraction of aquaporin4 in different temperatures (298k,300...

Human Leukocyte Antigen (HLA) complexes are critical cell-surface protein assemblies that facilitate T-cell surveillance of almost all cell types in the body. While receptor binding to HLA class I and II is well-described with detailed structural information, nature cis interactions within plasma membrane surveyed cells remains be better characterized, as protein-protein environment technically...

Leaf Veins The leaf vein is the “vascular system” in plants. In article 2201220 by Kelvin W. K. Yeung, Xin Zhao, and co-workers, a leaf-vein micropattern engraved on PGLADMA polymer membrane, serving as “running tracks” for vascular endothelial cells to facilitate hierarchical functional reconstruction. membrane can induce cell differentiation, vasculature reconstruction, vessel maturation.