background and objectives: classic hodgkin lymphoma (chl), anaplastic large cell lymphoma (alcl) and some cases of diffuse large b cell lymphoma (dlbcl) have overlapping morphologic features. since they all represent distinct clinico-pathologic entities, we explored the differential diagnostic impact of immunophenotyping to discriminate between them. materials and methods: we included 61 cases ...

Abstract Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare, non-Hodgkin which arises within the capsules of breast implants. These particular tumours have expression CD30 and are negative for Anaplastic Lymphoma Kinase (ALK). Here, we report case BIA-ALCL in 48-year-old woman post reconstruction. This aimed at raising awareness education on significance considering d...

1. Hansen SV, Nyvold CG, MH. Mantle cell lymphoma and the evidenceof an immature lymphoid component. Leuk Res. 2022;115:106824. doi: 10.1016/j.leukres.2022.106824. CrossRef Google Scholar

Follicular helper T-cell (TFH) lymphomas comprise a unique group of that represent neoplastic proliferations follicular T-cells and share genetic, immunophenotypic, morphologic, clinical features. Angioimmunoblastic lymphoma (AITL) is the prototypical TFH lymphoma; in addition, 2017 revised World Health Organization (WHO) 4th edition recognizes two other subtypes: (FTCL) nodal peripheral with T...

Lymphomas are neoplastic transformations that affect lymphoid cells. Diffuse large B-cell non-Hodgkin’s lymphoma has a high degree of cell proliferation, accounting for 30% all lymphomas. Lung cancer is the leading cause death worldwide and recommended treatment chemotherapy. Among main complications resulting from lymphoma, lung chemotherapy used in their treatment, we can mention sepsis, acut...

Abstract Chemo-immunotherapy has improved survival in B-cell lymphoma patients, but refractory/relapsed diseases still represent a major challenge, urging for development of new therapeutics. Karonudib (TH1579) was developed to inhibit MTH1, an enzyme preventing oxidized dNTP-incorporation DNA. MTH1 is highly upregulated tumor biopsies from patients with diffuse large (DLBCL) and Burkitt lympho...

  A male patient with acute renal failure (ARF) due to large B-cell non-Hodgkin lymphoma infiltration of kidney is presented. The diagnosis was suspected because of coincidence of ARF and tumor lysis syndrome non-responsive to conservative renal therapies. A renal biopsy confirmed diagnosis and appropriate chemotherapy led to complete improvement of renal function.  

Mycosis fungoides is a common form of cutaneous T-cell lymphoma, with characteristic histopathology and chronic clinical course. Vesiculobullous mycosis fungoides is a rare occurrence. Here we present a 55-year-old man with multiple bullous plaques of one year duration who was finally diagnosed as a case of mycosis fungoides.

langerhans cell histiocytosis (lch) is a rare neoplasm defined as the proliferation of bone marrow langerhans cells, which is a kind of dendritic cells. the major pathological features of lch are expression of cd1a and s100 as well as birbeck granules. its presentation can differ from a mild bone lesion to a multi-systemic evolved malignant neoplasm; however, the latter outcome is almost rare. ...

Non-Hodgkin lymphomas (NHLs) are increasing in incidence and will be diagnosed in more than 55,000 individuals this year alone [1,2]. The 13 most frequent clinical classes recognized in the lymphoma classification include diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), small lymphocytic lymphoma (SLL) mantle cell lymphoma (MCL), peripheral T-cell lymphoma (PTCL), marginal B-cel...