Objective(s): The present study was aimed to investigate the influence of thoracic epidural blockade on hypoxia-induced pulmonary hypertension in rats. Materials and Methods: Forty eight Wistar rats were randomly divided into 4 equal groups, named normoxia hypoxia hypoxia/ ropivacaine and hypoxia/saline. Animals were placed in a hypoxia chamber and instrumented with epidural catheters at the t...

Migration toward pathological area is the first critical step in microglia engagement during the central nervous system (CNS) injury, although the molecular mechanisms underlying microglia mobilization have not been fully understood. Here, we report that hypoxia promotes stromal cell-derived factor-1a (SDF-1a) induced microglia migration by inducing the CXC chemokine receptor 4 (CXCR4) expressi...

Hypoxia-induced angiogenesis is a common phenomenon in many physiological and patho-physiological processes. However, the potential differential roles of three hydrogen sulfide producing systems cystathionine γ-lyase (CSE)/H2S, cystathionine β-synthase (CBS)/H2S, and 3-mercaptopyruvate sulfurtransferase (MPST)/H2S in hypoxia-induced angiogenesis are still unknown. We found that minor hypoxia (1...

Hypoxia or lowering of the oxygen availability is involved in many physiological and pathological processes. At the molecular level, cells initiate a particular transcriptional program in order to mount an appropriate and coordinated cellular response. The cell possesses several oxygen sensor enzymes that require molecular oxygen as cofactor for their activity. These range from prolyl-hydroxyla...

Activation of vascular endothelium plays an essential role in vasoocclusion in sickle cell disease. The anti-inflammatory agents dexamethasone and adhesion molecule-blocking antibodies were used to inhibit endothelial cell activation and hypoxia-induced vasoocclusion. Transgenic sickle mice, expressing human alpha-, beta(S)-, and beta(S-Antilles)-globins, had an activated vascular endothelium i...

Purpose: Glioblastoma is an aggressive and incurable brain tumor whose progression driven in part by glioblastoma stem cells, which are also responsible for the tumor’s low therapy efficacy. The maintenance expansion of cell population promoted hypoxic microenvironment, where miRNAs play fundamental roles their survival. Methods: GBM stem-like cells were isolated from three parental lines. then...

Hypoxia (low oxygen) often occurs in aquatic ecosystems that receive effluent from municipal wastewater treatment plants (WWTP). The combination of hypoxia and WWTP could impair fish health, because contains multiple contaminants disrupt the physiological pathways use to cope with hypoxia, but interactive effects these stressors on physiology are poorly understood. We have examined this issue b...

Glioblastoma, a grade IV astrocytoma, has poor survival rate in part due to ineffective treatment options available. These tumours are heterogeneous with areas of low oxygen levels, termed hypoxic regions. Many intra-cellular signalling pathways, including DNA repair, can be altered by hypoxia. Since damage induction and subsequent activation repair mechanisms is the cornerstone glioblastoma tr...

The utilization of radiotherapy (RT) serves as the principal approach for managing nasopharyngeal carcinoma (NPC). Consequently, it is imperative to investigate correlation between radiation microenvironment and resistance in NPC. PubMed China National Knowledge Infrastructure (CNKI) databases were accessed perform a search utilizing English keywords “nasopharyngeal cancer”, “radiotherapy”, “mi...

Introduction Endometriosis is a reproductive disorder closely associated with hypoxia stress. Increasing evidences have implied the important roles of angiotensin II (ANG II) receptors in pathophysiology endometriosis. Thus, we speculated that Azilsartan (AZL), an ANG receptor blocker, might effective function controlling Material and methods The endometriotic animal model was established femal...