epilepsy as one of the most common neurological disorders affects more than 50 million people worldwide with a higher prevalence rate in low-income countries. excessive electrical discharges in neurons following neural cell damage or loss cause recurrent seizures. one of the most common and difficult to treat types of epilepsy is temporal lobe epilepsy (tle) which results from hippocampal scler...

While much work has been done in the design of biomaterials to control integrin-mediated adhesion, less emphasis put on functionalization materials with cadherin ligands. Yet, cell–cell contacts combination cell–matrix interactions are key driving embryonic development, collective cell migration, epithelial mesenchymal transition, and cancer metastatic processes, among others. This review focus...

: World population has been continuously raised and therefore due to this fact new source of foods, particularly proteins, are in demand. In recent years, single cell protein has been considered as an accepted substitute for animal and plant proteins. In this study, single cell protein production was studied in a batch submerged culture using Aspergillus niger PTCC5012. Experimental design was ...

YOHEI YOKOBAYASHI∗, CYNTHIA H. COLLINS∗, JARED R. LEADBETTER†, RON WEISS‡ and FRANCES H. ARNOLD∗,∗∗ ∗Division of Chemistry and Chemical Engineering, †Division of Engineering and Applied Science, California Institute of Technology 1200 E. California Blvd, Pasadena, CA 91125, USA ∗∗[email protected] ‡Department of Electrical Engineering, Princeton University, B-312, E-Quad, Princeton, NJ ...

background: generation of an effective dendritic cell (dc) based cancer vaccine depends on appropriate differentiation of monocytes in vitro. objective: to compare the effects of monocyte separation methods, flask adherence (flask-dc) and magnetic activated cell sorting (macs-dc), on phenotypic and functional characteristics of resultant dcs. methods: dcs from healthy volunteers were generated ...

the clinical potentials of stem cells in cell-based therapies have raised great hopes in diabetes mellitus as well. however, there are complex ethical, legal, and socio-cultural issues surrounding the subject. in this paper, we intend to review in brief the main ethical issues for endocrinologists and other clinicians who are interested and work in the field of cell therapy and research.

background: there is evidence that mesangial cell structural changes contribute to the pathogenesis of diabetic nephropathy. to gain better insight into the mechanisms responsible for this issue, present study focused on effect of cord blood mononuclear cells (mncs) derived cd133 positive cells on mesangial cell structure and function. materials and methods: the animals were randomly divided in...

background cancer stem cells play crucial roles in resistance to therapeutic schemes and relapse of disease, so it is important to find targeted therapies that kill them selectively. breast cancer is the most common cancer in females living in all part of the world including iran and it has an important burden in public health with direct impact on patients’ families. breast cancer in young adu...