Effects of increasing cefotaxime, carbenicillin and timentin concentrations on the in vitro morphogenesis of Eucalyptus grandis explants were evaluated. It was observed that carbenicillin and timentin increased the frequency of explant regenerating calluses and decreased necrosis up to 600 mg L-1, and that cefotaxime behaved similarly up to 300 mg L-1. At this level there was an increasing freq...

The interaction of cefpirome and a cephalosporinase from Citrobacter freundii, including hydrolysis and inhibition, was studied in comparison with those of cefotiam, cefotaxime, and ceftazidime. Cefpirome was hydrolyzed by the enzyme more rapidly at Vmax than were cefotaxime and ceftazidime. However, the low affinity of the enzyme for cefpirome caused a reduction in the hydrolytic rate of cefpi...

Salmonella meningitis is an unusual complication of Salmonella sepsis and occurs mainly in children. A rare case of Salmonella typhimurium meningitis occurring in an adult HIV positive man who presented with a history of fever and diarrhoea is reported. On examination he was dehydrated, and had oral thrush, weakness of lower limbs and neck stiffness. A septic diagnostic screen was performed and...

The susceptibilities of pneumococci recently collected (up to June 2009) in Spain (500 isolates nonsusceptible to oral penicillin and 150 susceptible isolates) from serotypes not included in the conjugate vaccine were determined. Most nonsusceptible isolates (53.6%) belonged to serotype 19A. Susceptibility rates in serotype 19A penicillin-intermediate (n = 201)/penicillin-resistant (n = 67) iso...

Ceftriaxone is a new, third-generation cephalosporin that, because of its long half-life, offers potential advantages of cost and convenience over similar agents such as cefotaxime. We compared the two drugs in a prospective, randomized study of the treatment of chest infections in seriously ill patients. Fifty-one patients (90 percent of whom were mechanically ventilated) received either ceftr...

The in vitro activities of moxalactam (LY127935 [6059S]) and cefotaxime were compared with those of cefoxitin, cefamandole, cefuroxime, carbenicillin, and penicillin by agar dilution susceptibility testing of a variety of anaerobic bacteria. Moxalactam proved to be the most active agent tested against Bacteroides fragilis and other species of the B. fragilis group. Moxalactam and cefotaxime sho...

The stability of the aminoglycosides gentamicin, tobramycin, and amikacin stored in combination with carbenicillin, piperacillin, cefotaxime, and moxalactam was evaluated at four temperatures (25, 4, -8, and -70°C) over a 3-week period. Amikacin was the most stable of the aminoglycosides and demonstrated no loss of activity when stored with either carbenicillin or piperacillin. Gentamicin and t...

The sensitivities of 226 clinical isolates of En~erobacteriaceae towards seven cephalosporin antibiotics were determined using an agar dilution method for establishing m.i.c. (minimum inhibitory concentration). The cephalosporins tested were cephaloridine, cephalothin, cephalexin, cefoxitin, cephradine, cefuroxime and cefotaxime. Cefotaxime showed the highest anti-bacterial activity among the c...

The in vitro activities of three new beta-lactam antimicrobial agents, cefodizime, ceftazidime, and aztreonam (formerly azthreonam), were compared with those of cefotaxime, cefuroxime, cefoxitin, and penicillin against 100 beta-lactamase-negative and 42 beta-lactamase-positive Neisseria gonorrhoeae strains. The three new antimicrobial agents showed excellent activity against N. gonorrhoeae rega...

This study investigated the synergy testing of penicillin, cephalosporin, amphenicols, and aminoglycoside in camel milk (n=768 samples), subsequently used for isolation MDR S. aureus targeting mecA gene. Antibiotic susceptibility showed >90% isolates were sensitive to ciprofloxacin trimethoprim resistant against oxacillin, ampicillin, cefoxitin. Further, 50-85% gentamicin, oxytetracycline, chlo...