AIMS Blood pressure (BP) changes in alcohol-dependent individuals during a 12-week alcohol relapse prevention study were examined in light of drinking status and biomarkers of alcohol consumption [carbohydrate-deficient transferrin (%CDT) and gamma-glutamyl transpeptidase (GGT)]. METHODS Of 160 randomized alcoholic individuals, 120 who had hypertension and in whom daily drinking data was avai...

Diagnostic accuracy of a computer assisted diagnostic system compared to conventional markers of alcoholism. Netherlands (van Lambalgen, professor of logic and artificial intelligence). Acknowledgements All laboratory tests, except carbohydrate-deficient transferrin (CDT) were performed in the ABSTRACT Context Conventional tests for alcoholism have good screening properties for detecting hazard...

Objective: Mini-mental state examination, a nonspecific measure of global cognitive function, and the clock drawing test, a very concise and specific measure of cognitive function, are among the most widely used screening tests for cognitive dysfunction. The present research aimed to examine the correspondence between MMSE and CDT scores. Methods: A total of 70 older adults (mean(SD) age=69.70...

In this study, we investigated in groups of female BALB/c mice injected with Crotalus durissus terrificus venom (Cdt) the renal function based on creatinine clearance, percentage of fractional excretion cytokines and histological examination of renal tissue. Cdt caused renal alterations that induced proteinuria during the initial hours post-venom and reduced creatinine clearance 15 min. up to 2...

The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is a heterotrimeric AB2 toxin capable of inducing lymphocytes, and other cell types, to undergo cell cycle arrest and apoptosis. Exposure to Cdt results in binding to the cell surface followed by internalization and translocation of the active subunit, CdtB, to intracellular compartments. These events are dependent upon...

INTRODUCTION Chest desmoid tumors (CDT) are rare lesions characterized by fibroblastic proliferation from the connective tissue. Although CDT have been studied previously, no cases following subfascial transaxillary breast augmentation (TBA) have been described. PRESENTATION OF CASE The authors describe a case of CDT in a 28-year-old woman one year after TBA, which presented as a painful and ...

This report evaluates the efficiency and safety of catheter-directed thrombolysis (CDT) using tissue plasminogen activator (tPA) and argatroban for the treatment of IVC filter thrombosis complicated by heparin-induced thrombocytopenia (HIT). From October 2012 to December 2014, 19 patients with unilateral lower extremity deep venous thrombosis were treated with standard anticoagulation, filter p...

Delaunay Triangulation (DT) and its extension Constrained Delaunay Triangulation (CDT) are spatial data structures that have wide applications in spatial data processing. Our recent survey shows, however, that there is a surprising lack of algorithms for computing DT/CDT for large spatial databases. In view of this, we propose an efficient algorithm based on the divide and conquer paradigm. It ...

A test was constructed by combining carbohydrate-deficient transferrin (%CDT) and gamma-glutamyltransferase (GT) and was evaluated in detecting alcohol-dependent patients in a surgical ward. The performance of the combined test was significantly better than that of either %CDT alone or GT alone, as evaluated by calculating sensitivity and likelihood ratio at a specificity of 0.85 and by compari...

Many bacterial pathogens encode the cytolethal distending toxin (CDT), which causes host cells to arrest during their cell cycle by inflicting DNA damage. CDT is composed of three proteins, CdtA, CdtB, and CdtC. CdtB is the enzymatically active or A subunit, which possesses DNase I-like activity, whereas CdtA and CdtC function as heteromeric B subunits that mediate the delivery of CdtB into hos...