Different forms of glucose-6-phosphate dehydrogenase (G-6-PD) have been described in different tissues. Moreover, the directly determined amino acid sequence amino end of the red cell enzyme does not exactly match the sequence deduced from cDNA isolated from HeLa cells or lymphoblasts. We have therefore investigated the sequence of cDNA from sperm, granulocytes, reticulocytes, brain, placenta, ...

General biological databases that store basic information on genome, transcriptome, and proteome are indispensable sequence discovery resources. However, they are not necessarily useful for inferring functions of proteins. To see this, we observe that SWISS-PROT —a protein knowledgebase containing curated protein sequences and functional information on domains and diseases—has grown a mere 26-f...