luteolin is a flavone in medicinal plants as well as some vegetables and spices. it is a natural anti-oxidant with less pro-oxidant potential but apparently with a better safety profile. the purpose of this study was to investigate the molecular mechanism of luteolin-mediated apoptosis of mg-63 human osteosarcoma cells. mtt assay kit was employed to evaluate the effects of luteolin on mg-63 cel...

it has been reported that several conifers possess cytotoxic activities on some human tumor cell lines. taxol as a natural cytotoxic compound has been extracted from this family. in a program to screen the cytotoxic effects of natural resources, male and female branchlets, fruit or bark of two different species of iranian conifers were collected, identified and the cytotoxic effects of their hy...

background: arsenic is one of the most toxic metalloids. anemia and leukopenia are common results of poisoning with arsenic, which may happen due to a direct hemolytic or cytotoxic effect on blood cells. the aim of this study was to examine the effects of hydroalcoholic extract of nasturtium officinale on blood cells and antioxidant enzymes in rats exposed to sodium (meta)arsenite. methods: 32 ...

background: essential oils are found to have multiple active components which can show in vitro cytotoxic action against various cancerous cell lines. this study reports the in vitro cytotoxic effects of the essential oil from artemisia absinthium l. (asteraceae) growing wild in iran. methods: water-distilled essential oil of a. absinthium collected from ardabil, north-western iran, was examine...

background and aims: each year, the influenza virus causes moderate to severe infections with a high prevalence throughout the world. accordingly, an influenza vaccine that ensures protection with only a single dose would be a much more cost effective approach to influenza prophylaxis. generation of influenza non-replicating virus-like particles (vlp) in baculoviral expression system is an attr...

abstract: peganum harmala l. (zygophylaceae) has been used in a variety of practical applications in medical science. our objective in the current study was to determine the effects of the seed extract on herpes simplex virus type 1 (hsv-1) replication in vero cells. different concentrations (100, 500, 571, 667, 800 and 1000 µg/ml) of the extract were examined. experiments were carried out usin...

background and objectives: hbha and mtb32c have been isolated from culture supernatants of mycobacterium tu- berculosis (m. tuberculosis) and mycobacterium bovis (m. bovis) and their immunogenicity previously studies have been confirmed. in this study, capability of constructed vector containing two mycobacterial immunodaminant antigens (mt- b32c-hbha), in producing new chimeric protein under t...

angiocardiography is an x-ray examination of the blood vessels or chambers of the heart. cardiologists and staff members applying this procedure are exposed to high levels of scattered radiation. in our previous study the incidence of unstable chromosomal aberrations and cytokinesis-blocked micronuclei were found to be significantly higher in exposed individuals than the age and sex matched con...

introduction: satellite cells are known as the main regenerative cell type in skeletal muscles. our study established a modified digestion and preplating method for the isolation of slow or weak adherent cells for the enrichment of satellite cells. low-survival rate of these primary stem cells prompted us to address whether cell culture medium substitution might change cell viability status. me...

background: diabetes is a major public health problem. the development of new therapies that are able to improve glycemia management and even to cure diabetes is of great interest. in this study, protective effects of sodium tungstate against stz-induced beta-cell damages were investigated. methods: sixty rats were divided into six groups: control, diabetic, sodium tungstate treated diabetic ra...