In previous studies, we have demonstrated the inhibition of CD4 expression in rat lymphocytes treated with phorbol myristate acetate (PMA) by antisense oligonucleotides (AS-ODNs) directed against the AUG start region of the cd4 gene. The aim of the present study was to inhibit CD4 expression in lymphocytes without promoting CD4 synthesis and to determine the effect of this inhibition on CD4+ T ...

background: patients with rheumatoid arthritis (ra) suffer from wide ranges of autoimmune reactions in joints. the mechanism of which is generally unknown and maybe associated with treg deregulation. objective: to compare the frequency of ntregs in peripheral blood of patients with active rheumatoid disease with healthy individuals. methods: twenty five newly diagnosed patients with active ra d...

in traditional chinese medicine, arsenous compounds, including arsenic trioxide (ato), are often used to treat many diseases, which are safe and effective. recently, studies have indicated that th17– il-17 involved in the pathogenesis and development of asthma. the goal of this study was to investigate the effect and mechanism of ato on asthma, especially the th17– il-17 axis. we used oval bumi...

Introduction: A unique feature of Hodgkin lymphoma (HL) is the presence CD4+ T cells that surround, protect, and promote survival tumor cells. It was described primary EBV infection elicits EBV-specific with cytotoxic proteins. Since in Argentina, a high incidence EBV-associated pediatric cases, our aim to evaluate influence on CD4+T at microenvironment patients. Methods: 42 patients HL were in...

Abstract Introduction/Objective T-cell large granular lymphocytic leukemia (T-LGL) is a lymphoma with persistently increased lymphocytes in peripheral blood. The majority of T-LGL associated CD8+ T-cells. However, the CD4+ variant uncommonly seen. Methods/Case Report patient 49-year-old female history diabetes mellites and anemia who presented shortness breath, lower extremities edema, fatigue....

Background: Regulatory T cells have been suggested to have a protective role against acute rejection in allograft recipients. However, there is little information available about their contribution to chronic rejection process. The role of transforming growth factor-beta 1 (TGF- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. Objectives: To eva...

Background: Dendritic cells (DC) are a key regulator of the immune response, and interferon- beta (IFN-β) is considered an immunomodulatory molecule for DC. Objective: The purpose of this study was to evaluate the ability of IFN-β treated DC to induce cytokine secretion by CD4+ T cells. Methods: Dendritic cells were generated from blood monocytes with granulocyte-monocyte colony-stimulating fac...

Infertile marriage is a complex socio-economic problem; the frequency of infertility in Ukraine 17-20%, which prompts further study its mechanisms, including immune ones, order to develop appropriate methods correction. Purpose - characterize phenotypic features T-cells and their subpopulation T-helpers (CD3+CD4+) with expression intracellular cytokines women history at different stages pregnan...

Sezary syndrome (SS) is the leukemic variant of CD4+ cutaneous T-cell lymphoma. Mogamulizumab an FDA-approved monoclonal antibody targeting surface CCR4 on SS cells. We’ve previously described highly expressed biomarker genes and altered cytokine gene expression that favors a Th2-immune phenotype. Here we evaluated mogamulizumab’s efficacy in reducing malignant T-cells, decreasing expression, m...