After a short introduction to place our work in a proper context, this account summarizes our theoretical and synthetic results in the field of frustrated Lewis pair (FLP) chemistry.

E-selectin elicits cell adhesion by binding to the cell surface carbohydrate, sialyl Lewis X (sLe(x)). We evaluated the effects of mutations in the E-selectin lectin domain on the binding of a panel of anti-E-selectin mAbs and on the recognition of immobilized sLe(x) glycolipid. Functional residues were then superimposed onto a three-dimensional model of the E-selectin lectin domain. This analy...

We present some results that show the information of sign structure of matrices characterized by signed digraph can reduce computations in interval matrices. With the sign structure of the matrices, vertices of interval matrices which realizes the max/min of the determinant can be xed. We present an algorithm to check singularity of interval matrices based on the result. We also discuss impact ...

The Lewis X (Le(X)) antigen is a prognostic marker in certain solid tumors and has been proposed as a therapeutic target. Immunohistochemical analyses were performed to retrospectively examine the prognostic impact of Le(X) expression in 158 patients with triple-negative breast cancer (TNBC). Twenty-three (14.5%) patients were Le(X)-positive. Multivariate analysis showed that Le(X) positivity w...

Frustrated Lewis pair (FLP) chemistry enables a rare example of alkyne 1,2-hydrocarbation with N-methylacridinium salts as the carbon Lewis acid. This 1,2-hydrocarbation process does not proceed through a concerted mechanism as in alkyne syn-hydroboration, or through an intramolecular 1,3-hydride migration as operates in the only other reported alkyne 1,2-hydrocarbation reaction. Instead, in th...

LEX and YACC (or FLEX and BISON) allow a compiler writer to generate scanners and parsers from simple speciications, but scanning and parsing account for only about 15% of a typical compiler. Tool support is now available for the other 85%. This paper explains how new and existing tools have been combined in a domain-speciic programming environment that reduces compiler development eeort to abo...

Helicobacter pylori NCTC 11637 lipopolysaccharide (LPS) expresses the human blood group antigen Lewis x (Le(x)) in a polymeric form. Le(x) is beta-D-galactose-(1-4)-[alpha-L-fucose-(1-3)]-beta-D-acetylglucosamine. Schematically the LPS structure is (Le(x))n-core-lipid A. In this report, we show that Le(x) expression is not a stable trait but that LPS displays a high frequency (0.2 to 0.5%) of p...

Machine Learning techniques are useful tools for the automatic extension of existing lexical databases. In this paper, we review some symbolic machine learning methods which can be used to add new lexical material to the lexicon by automatically inducing the regularities implicit in lexical representations already present. We introduce the general methodology for the construction of inductive l...

Conditions have been established for the rapid and efficient conjugation of reducing oligosaccharides (di- to deca-saccharides) to dipalmitoyl phosphatidylethanolamine. The resulting neoglycolipids derived from several naturally occurring oligosaccharides and a series of N-linked high-mannose-type oligosaccharides released by hydrazinolysis from RNAase B showed specific and potent reactivities,...

P-selectin binding to neutrophils requires a specific protein, P-selectin glycoprotein ligand 1 (PSGL-1), as well as sialyl-Lewis X (sLex) glycan determinants. We have found that a short segment near the amino terminus of PSGL-1 that contains a tyrosine sulfation consensus is essential for P-selectin adhesion and that addition of the amino-terminal segment to some but not all mucin-like molecul...