BACKGROUND AND PURPOSE We tested the hypothesis that inhibiting nitric oxide production either before or during transient focal ischemia affects early postischemic brain injury. METHODS Halothane-anesthetized cats underwent 1 hour of left middle cerebral artery occlusion plus 3 hours of reperfusion. Pretreatment groups received either intravenous N omega-nitro-L-arginine methyl ester (L-NAME;...

abstract background: high resolution ct scan has made early diagnosis of intraventricular hemorrhage (ivh) easier. posttraumatic intraventricular hemorrhage has been reported to a greater extent because of the ct scan. methods: 904 patients were admitted in the nsicu from march 2001 to march 2002 with severe closed head injury, of those only 31 patients with intraventricular hemorrhage (gcs les...

Background: The involvement of frontostriatal circuits in Frontotemporal Dementia (FTD) suggests that deep gray matter structures (DGM) may be affected in this disease. Objective: We investigated whether volumes of DGM structures differed between patients with bvFTD, Alzheimer’s Disease (AD) and subjective complaints (SC) and explored relationships between DGM structures, cognition and neuropsy...

1 The release of 5-hydroxytryptamine (5-HT) from the cerebral cortex and caudate nucleus of brainstem-transected cats and from the cerebral cortex of rats anaesthetized with urethane was determined by radioenzymatic and biological assay. 2 The stimulation of nucleus linearis intermedius of raphe doubles the basal 5-HT release in the caudate nucleus and increases it 3 fold in the cerebral cortex...

BACKGROUND AND PURPOSE Accumulation of iron after intracerebral hemorrhage causes free radical formation and oxidative damage resulting in liquefaction. The aim of this study was the investigation of molecular mechanisms underlying estrogen-mediated neuroprotective effect against iron-induced brain injury in vivo. METHODS Age-matched male and female Sprague-Dawley rats were stereotaxically in...