Åsgård, R. 2014. Effects of Antioxidants and Pro-oxidants on Oxidative Stress and DNA Damage using the Comet Assay. Studies on Blood Cells from Type 2 Diabetes Subjects and Mouse Lymphoma Cells. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 185. 78 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-8877-2. Diet and oral supplements comprise two ...

Die muschelinspirierte Polymerisation (MIPoly) stellt, inspiriert durch die Bildung von Cysteinyldopa als biogene Verknüpfungseinheit, eine Möglichkeit dar, um synthetisch adhäsive Polymere herzustellen. Hierbei wird große Familie der chemisch vielfältigen Bisphenolmonomere eingesetzt, 2-Iodoxybenzoesäure zu Dichinonen aktiviert werden kann. Diese Dichinone reagieren in Michael-artigen Polyaddi...

The synergic antioxidant activity of ?-terpinene with ?-tocopherol, its synthetic analogue 2,2,5,7,8-pentamethyl-6-chromanol (PMHC), BHT, TBHQ, and catechol was studied by measuring the O2 uptake hydroperoxide formation in stripped sunflower oil at 130 °C. Although inactive when used alone, it prolonged, a concentration-dependent manner, protecting ?-tocopherol PMHC, while had no effect on cate...

An asymmetric intermolecular Stetter reaction of enals with nitroalkenes catalyzed by chiral N-heterocyclic carbenes has been developed. The reaction rate and efficiency are profoundly impacted by the presence of catechol. The reaction proceeds with high selectivities and affords good yields of the Stetter product. Internal redox products were not observed despite of the protic conditions. The ...

We report that an amphiphilic bis-catechol (3) functions as a transmembrane anion transporter. Activity depends on the catechol's substitution and amphiphilicity. We also describe a liposomal assay that allows one to readily measure anion transport selectivity. This assay reveals that anion transport selectivity for this amphiphilic bis-catechol follows a Hofmeister sequence wherein anions that...

Certain Mycobacteriu form adaptive enzymes for the oxidation of benzoic acid (1). The oxidation proceeds through catechol and protocatechuic acid (2) and is thus similar to that in PseudomonasJEuorescens (3). Neither cyclohexanecarboxylic acid nor any substituted benzoic acid is oxidized by these Mycobacteria, but certain of these compounds can induce the organism to form adaptive enzymes for b...

Immunization of rabbits with purified catechol methyltransferase from Candida tropicalis yielded a potent antiserum. Ouchterlony double diffusion analysis showed a single precipitin line. There was no cross reactivity with the catechol methyltransferase from rat and bovine liver. Specific antigen-antibody interaction was demonstrated by a potent inhibitory effect of the antibody on the yeast en...

Six strains were isolated from Lake Akşehir (Konya-Turkey) and identified as Rhodopseudomonas palustris on the basis of physiological and morphological characteristics. The strains grew phototrophically on a variety of aromatic compounds (under illuminated anaerobic conditions), namely, benzoate, hippurate, benzyl alcohol, 2-amino benzoic acid, phloroglucinol, phenylacetic acid, catechol, pyrid...

Infusions of 2.5-7.8 ng. noradrenaline/Kg./min. over 30 min. and intruperitonenl injections of noradrenaline and adrenaline up to 2000 Mg/Kg. in the cat had no effect on the catechol amine content of the. heart, spleen, liver, kidney and skeletal muscle, except for a slight increase in the adrenaline content. It is concluded that these organs lack the ability to accumulate i-iirulating catechol...

Exposure to estrogens is a risk factor for human breast cancer. Experiments on estrogen metabolism, formation of DNA adducts, carcinogenicity, mutagenicity and cell transformation led to and support the hypothesis that reaction of specific estrogen metabolites, catechol estrogen-3,4-quinones, with DNA can generate the critical mutations to initiate breast, prostate and other human cancers. The ...