mycophenolic acid (mpa) is the active metabolite of mycophenolate mofetil. this study designed to investigate the mechanism of cytotoxicity of mpa on the genetically engineered pc12 tet off (pto) neuronal cells with p53 gene. alamar blue (ab) reduction showed concentration-dependent cytotoxicity of mpa on pto cells with ic50 value of 32.32 ± 4.61 mm. the reactive oxygen species (ros) generation...

Gemcitabine is an important anticancer therapeutics approved for treatment of several human cancers including locally advanced or metastatic pancreatic ductal adenocarcinoma (PDAC). Its clinical effectiveness, however, is hindered by existence of intrinsic and development of acquired resistances. Previously, it was found that 14-3-3σ expression associates with poor clinical outcome of PDAC pati...

Pyroptosis is a type of acute cell death that mainly occurs in immune cells. It characterized with robust release inflammatory cytokines and has emerged to play critical role the pathogenesis sepsis-associated disorders. In this study, we screened for pyroptotic inhibitors ultimate goal benefit sepsis treatments. Accidentally, identified nitrosonisoldipine (NTS), photodegradation product calciu...

Staphylococcus aureus is the leading cause of skin and soft tissue infections. With emergence antibiotic-resistant bacteria, there an unmet clinical need to develop novel therapies treat The inflammasome components involved in response S. stimulation are well established vitro immune cell cultures. However, formation cells during vivo infections not entirely understood. Therefore, we used mouse...

Necroptosis is a regulated necrotic-like cell death modality which has come into the focus of attention since it known to contribute pathogenesis many inflammatory and degenerative diseases as well tumor regulation. Based on current data, necroptosis serves backup mechanism when receptor-induced apoptosis inhibited or absent. However, necroptotic role proteins involved in mitochondrial not been...

Apoptosis plays an important role in the development of acute inflammatory lung injury (AILI) and its consequences, which can be realized different cells with distinct intensity rate. The aim this study was to determine distribution expression apoptosis markers lungs rats AILI model endotracheal introduction capron thread LPS. Immunoblotting immunohistochemical studies were performed using mono...

associated with inability to extinguish these fear memories, & hippocampal atrophy, & increase the risk of neurodegenerative disease. Studies showed that apoptosis is a neurodegenerative process that has important role in that ,although volume & function of hippocampus reduce by the chronic effect of glucocorticoids. Hippocampal steroid receptors control the HPA axis. Glucocorticoids involve in...

In this issue of Circulation Research, Syed et al 1 report that overexpression of caspase-1 (ICE) contributes to myocardial ischemia/reperfusion injury. Transgenic mice were generated using the alpha-myosin heavy chair promoter to drive caspase-1 expression in the heart. The mice expressed caspase-1 30-fold more than the nontransgenics. Despite this massive overexpression, no spontaneous caspas...