BACKGROUND We used self-administered vaginal swabs to assess the incidence and clearance of carcinogenic human papillomavirus (HPV) infections in rural Rakai, Uganda. METHODS Women provided self-administered vaginal swab at annual home-based visits. Type-specific carcinogenic HPV incidence and clearance and risk factors were assessed. RESULTS Carcinogenic HPV incidence was 17.3 per 100 pers...

Mouse models for colon cancer that harbor a germ line mutation in the tumor suppressor gene Adenomatous polyposis coli (Apc) exhibit a primary genetic defect that predisposes to a high incidence of adenomatous polyps in the small intestine rather than in the colon. Colon cell culture models expressing quantifiable markers for carcinogenic risk may represent an alternative approach to reduce, re...

BACKGROUND The aim of this work was to establish recommendations for the medical follow-up of workers currently or previously exposed to carcinogenic substances for the bladder. METHODS A critical synthesis of the literature was conducted. Sectors of activity where workers are or were exposed to carcinogenic substances for the bladder were listed and classified according to the level of bladd...

Northern wild rice is of great dietary and cultural importance to the Native American population in Upper Peninsula Michigan. Millions tons mine tailings were discharged into Lake Superior other inland lakes during copper mining boom early 20th century this area. This includes L’Anse Bay, located within Keweenaw Bay Indian Community (KBIC) reservation. Since restoration being encouraged by KBIC...

We assessed whether infection with chlamydia increases the incidence of carcinogenic human papillomavirus (HPV) infections and if HPV persistence is affected by chlamydia co-infection. For 1982 women (16-29 years-old) participating in two consecutive rounds of a chlamydia screening implementation trial, swabs were polymerase chain reaction tested to detect chlamydia and 14 carcinogenic HPV geno...

The Sn-W Panasqueira mine, in activity since the mid-1890s, is one of the most important economic deposits in the world. Arsenopyrite is the main mineral present as well as rejected waste sulphide. The long history is testified by the presence of a huge amount of tailings, which release considerable quantities of heavy metal(loid)s into the environment. This work assesses soil contamination and...

Quantitative estimates of human carcinogenic risk from chemical exposure are currently derived primarily from linearized multistage model analyses of the tumor response as observed in chronic laboratory animal bioassays versus administered dose. The numerous ad hoc assumptions that provide a rationale for this generic approach to carcinogenic risk assessment can only be evaluated critically whe...

The contamination of tea as one most widely consumed beverage in Iran with the potentially toxic elements (PTEs) leads to adverse health effects. In current study, a meta-analysis and probabilistic risk assessment regarding PTEs concentration samples from were performed using international databases (PubMed Scopus) national (SID, Irandoc, Magiran) 2005 1 June 2022. Data analysed random-effects ...