BACKGROUND The extrinsic apoptotic pathway initiates when a death ligand, such as the Fas ligand, interacts with its cell surface receptor (ie., Fas/CD95), forming a death-inducing signaling complex (DISC). The Fas-dependent apoptotic pathway has been implicated in several models of lung or vascular injury. Carbon monoxide, an enzymatic product of heme oxygenase-1, exerts antiapoptotic effects ...

Carbon monoxide can produce several nonspecific symptoms and can mimic several diseases. Most of the signs and symptoms are due to hypoxia, which affects mainly the brain. The most significant neurologic and psychiatric manifestations of carbon monoxide poisoning are seen as subacute or late sequelae, often following a period of complete recovery from an acute episode. There is a possible inter...

A study of detonations in high molecular weight hydrocarbon fuels was performed in two GALCIT facilities: the 280 mm gaseous detonation tube (GDT) and a 1180 liter vessel (HYJET) with jet initiation capability. In the GDT, detonation pressure, wave speed and cell width measurements were made in hexane-oxygen-nitrogen mixtures with and without the addition of lower molecular weight fuels. Stoich...

Carboxyhaemoglobin (COHb) levels were studied in 11 249 men. The distribution among the 2613 men who smoked cigarettes was well separated from that in 6641 non-smokers (including ex-smokers). The distribution for 2005 cigar and pipe smokers was intermediate, though some of the highest COHb levels occurred in cigar smokers. Using a COHb cut-off level of 2%, 81% of cigarette smokers, 35% of cigar...

Graphene oxide holds promise as a carbon-based nanomaterial that can be produced inexpensively in large quantities. However, its structural and electrical properties remain far from those of the graphene sheets obtained by mechanical exfoliation or by chemical vapor deposition—unless efficient reduction methods that preserve the integrity of the parent carbon-network structure are found. Here, ...

An inactive, Ni-deficient form of carbon monoxide (CO) dehydrogenase [carbon-monoxide:(acceptor) oxidoreductase; EC 1.2.99.2], designated apo-CO dehydrogenase, accumulated in Rhodospirillum rubrum when cells were grown in the absence of Ni and treated with CO. In vivo, both CO dehydrogenase activity and hydrogenase activity increased several hundred fold upon addition of 2 microM NiCl2. Apo-CO ...

BACKGROUND Ototoxic effects of carbon monoxide exposure: a review. AIM To analyze the literature on hearing and Carbon Monoxide (CO). METHODS To describe the physical properties, the absorption, distribution and metabolism of CO, as well as its origin, production, sources and the international standards for occupational exposure. Several studies about the effects of CO exposure to the audit...

The current study aims at modelling the dispersion of two pollutants, namely CO (carbon monoxide) and SO2 (sulfur dioxide) released from District 7 of Tehran Municiaplity, from 20 main line sources, by means of CALPUFF modeling system. CALPUFF is a non-steady state puff modeling software which employs meteorological, terrain, and land-use data to effectively simulate air pollutants' dispersion ...

The impact of low-level carbon monoxide exposure on ventricular arrhythmia frequency in patients with ischemic heart disease has not been thoroughly studied. The issue is of concern because of the potential proarrhythmic effect of carbon monoxide in patients with ischemic heart disease. We studied 30 subjects with well-documented coronary artery disease who had an average of at least 30 ventric...