Respiratory diseases negatively impact the global goat industry, but are understudied. There is a shortage of established and biological relevant in vitro or ex vivo assays to study caprine respiratory infections. Here, we describe establishment an system based on well-differentiated airway epithelial cell (AEC) cultures grown under air liquid interface conditions as experimental platform patho...

Caprine arthritis encephalitis (CAE) is a retroviral infection of goats. CAEV is closely related to the virus which causes MaediVisna in sheep and AIDS in humans. The first survey of the seroprevalence of CAEV in Hungarian goats was performed. Parallel with it we tried to ascertain whether there is any association between either the susceptibility of CAE or the appearance of clinical symptoms i...

To determine the molecular basis of heterosis in goats, fluorescence quantitative polymerase chain reaction (PCR) was performed to investigate myosin-regulatory light chain 2 (MRLC2) gene expression in the longissimus dorsi muscle tissues of the Tianfu goat and its parents, the Boer and Chengdu Ma goats. The goat MRLC2 gene was differentially expressed in the crossbreed, and the purebred mRNA w...

The term “slow infection” was introduced for the first time by the Icelandic researcher B. Sigurdsson in 1954 (Sigurdsson, 1954). With this term, he designated the interaction of the virus with the host, characterized by a prolonged (many months and even years) incubation period, at what time several organs or systems become affected and thereafter, results in slow, but progressive development ...

Visna virus of sheep and arthritis-encephalitis virus of goats are serologically related but genetically distinct retroviruses which cause slowly progressive diseases in their natural hosts. To localize homologous regions of the DNAs of these two viruses, we constructed a physical map of caprine arthritis-encephalitis virus DNA and aligned it with the viral RNA. Cloned probes of visna virus DNA...